Trifluoro-methanesulfonic acid 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl ester
• CAS No.: 351002-11-4
• Molecular Formula: C14H12F3NO6S
• Molecular Weight: 379.314
• Mol file: 351002-11-4.mol

Synonyms:trifluoro-methanesulfonic acid 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl ester;2-morpholino-4-oxo-4H-chromen-8-yl trifluoromethanesulfonate;trifluoromethanesulfonic acid 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl ester;trifluoro-methanesulfonic acid 2-morpholin-4-yl-4-oxo-4H-1-benzopyran-8-yl ester;2-(4-morpholinyl)-8-trifluoromethanesulfonyloxy-4H-1-benzopyran-4-one;2-morpholin-4-yl-4-oxo-4H-chromen-8-yl trifluoromethanesulfonate;

Chemical Property of Trifluoro-methanesulfonic acid 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl ester

Chemical Property:

• Melting Point: 136 - 138 °C
• PSA: 94.43000
• LogP: 3.00380

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trifluoro-methanesulfonic acid 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl ester

There total 23 articles about Trifluoro-methanesulfonic acid 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

trifluoromethanesulfonic acid 2-hydroxy-3-(3-morpholin-4-yl-3-oxopropionyl)phenyl ester (503469-17-8) → trifluoromethanesulfonic acid 2-(morpholin-4-yl)-4-oxo-4H-chromen-8-yl ester (351002-11-4)

Guidance literature:

trifluoromethanesulfonic acid 2-hydroxy-3-(3-morpholin-4-yl-3-oxopropionyl)phenyl ester; With trifluoromethylsulfonic anhydride; In dichloromethane; at 20 ℃;

With methanol; at 20 ℃; for 4h;

DOI:10.1071/CH03113

Reference yield: 53.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + 8-Hydroxy-2-(4-morpholinyl)-4H-1-benzopyran-4-one (130735-95-4) → trifluoromethanesulfonic acid 2-(morpholin-4-yl)-4-oxo-4H-chromen-8-yl ester (351002-11-4)

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1021/ol062297x

Reference yield:

methyl-2,3-dihydroxybenzoate (2411-83-8) → trifluoromethanesulfonic acid 2-(morpholin-4-yl)-4-oxo-4H-chromen-8-yl ester (351002-11-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: K₂CO₃ / acetonitrile / 9 h / Heating

2.1: LDA / tetrahydrofuran / 1 h / -78 - -10 °C

2.2: 85 percent / tetrahydrofuran / 2 h / -78 - 20 °C

3.1: 99 percent / nBu₄NI; TiCl₄ / CH₂Cl₂ / 2 h / -78 - 0 °C

4.1: 92 percent / Tf₂O / CH₂Cl₂ / 15 h / 20 °C

5.1: 93 percent / DABCO / Rh(PPh₃)3Cl / ethanol / 3 h / Heating

6.1: 53 percent / Et₃N / tetrahydrofuran

With 1,4-diaza-bicyclo[2.2.2]octane; trifluoromethylsulfonic anhydride; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; lithium diisopropyl amide; Wilkinson's catalyst; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

DOI:10.1021/ol062297x

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

8-Hydroxy-2-(4-morpholinyl)-4H-1-benzopyran-4-one

trifluoromethanesulfonic acid 2-hydroxy-3-(3-morpholin-4-yl-3-oxopropionyl)phenyl ester

1-(3-allyloxy-2-hydroxyphenyl)ethanone

Downstream raw materials:

LY 294002