Ethyl 4-fluoro-3-hydroxybenzoate

Base Information

• Chemical Name: Ethyl 4-fluoro-3-hydroxybenzoate
• CAS No.: 351317-28-7
• Molecular Formula: C9H9FO3
• Molecular Weight: 184.167
• Hs Code.: 2918290000
• European Community (EC) Number: 609-070-2
• DSSTox Substance ID: DTXSID70592462
• Wikidata: Q82486590
• Mol file: 351317-28-7.mol

Synonyms:ETHYL 4-FLUORO-3-HYDROXYBENZOATE;351317-28-7;Ethyl4-fluoro-3-hydroxybenzoate;ethyl 3-hydroxy-4-fluorobenzoate;4-fluoro-3-hydroxy-benzoic acid ethyl ester;SCHEMBL190719;DTXSID70592462;QBOPWLOHFBLVGT-UHFFFAOYSA-N;BS-28234;DB-334152;E97804;EN300-1178549

Chemical Property of Ethyl 4-fluoro-3-hydroxybenzoate

Chemical Property:

• Vapor Pressure: 0.0019mmHg at 25°C
• Boiling Point: 283oC at 760 mmHg
• Flash Point: 124.9oC
• PSA: 46.53000
• Density: 1.257g/cm3
• LogP: 1.70800
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 184.05357231
• Heavy Atom Count: 13
• Complexity: 184

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-fluoro-3-hydroxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC(=C(C=C1)F)O

Technology Process of Ethyl 4-fluoro-3-hydroxybenzoate

There total 1 articles about Ethyl 4-fluoro-3-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + 4-fluoro-3-hydroxybenzoic acid (51446-31-2) → ethyl 3-hydroxy-4-fluorobenzoate (351317-28-7)

Guidance literature:

With sulfuric acid; Reflux;

Reference yield: 100.0%

cyclopropylcarbinyl bromide (7051-34-5) + ethyl 3-hydroxy-4-fluorobenzoate (351317-28-7) → Ethyl 3-(cyclopropylmethoxy)-4-fluorobenzoate (1213256-62-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 5h;

DOI:10.1021/jm3004174

Reference yield: 92.0%

ethyl 3-hydroxy-4-fluorobenzoate (351317-28-7) → 4-fluoro-3-hydroxybenzohydrazide (1182368-04-2)

Guidance literature:

With hydrazine hydrate; In ethanol; water; Reflux;

upstream raw materials:

ethanol

4-fluoro-3-hydroxybenzoic acid

Downstream raw materials:

4-fluoro-3-(2-morpholin-4-yl-ethoxy)-benzoic acid ethyl ester

4-fluoro-3-(2-piperidin-1-yl-ethoxy)-benzoic acid ethyl ester

4-fluoro-3-(2-methoxy-ethoxy)-benzoic acid ethyl ester

3-(2-methoxy-ethoxy)-4-(2-pyrrolidin-1-yl-ethoxy)-benzoic acid ethyl ester