2-(Dichloromethyl)-1,1,1-trifluoro-4-phenylbutan-2-ol

Base Information

Chemical Name:2-(Dichloromethyl)-1,1,1-trifluoro-4-phenylbutan-2-ol
CAS No.:356073-59-1
Molecular Formula:C11H11Cl2F3O
Molecular Weight:287.109
Hs Code.:
DSSTox Substance ID:DTXSID701212215
Nikkaji Number:J1.583.512E

Synonyms:356073-59-1;DTXSID701212215;alpha-(Dichloromethyl)-alpha-(trifluoromethyl)benzenepropanol

Suppliers and Price of 2-(Dichloromethyl)-1,1,1-trifluoro-4-phenylbutan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-(Dichloromethyl)-1,1,1-trifluoro-4-phenylbutan-2-ol

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:286.0139048
Heavy Atom Count:17
Complexity:239

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CCC(C(Cl)Cl)(C(F)(F)F)O

Technology Process of 2-(Dichloromethyl)-1,1,1-trifluoro-4-phenylbutan-2-ol

There total 1 articles about 2-(Dichloromethyl)-1,1,1-trifluoro-4-phenylbutan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 3277-89-2
phenethylmagnesium bromide

: 126266-75-9
3,3-dichloro-1,1,1-trifluoroacetone

: 356073-59-1
1,1-dichloro-2-trifluoromethyl-4-phenylbutan-2-ol

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.tet.2003.09.098

Reference yield: 93.0%

: 591-51-5
phenyllithium

: 356073-59-1
1,1-dichloro-2-trifluoromethyl-4-phenylbutan-2-ol

: (1RS,2SR)-1,2-epoxy-1,4-diphenyl-2-trifluoromethylbutane

Guidance literature:: In tetrahydrofuran; diethyl ether; cyclohexane; at -98 - -78 ℃;
DOI:10.1016/j.tet.2003.09.098

Reference yield: 60.0%

: 75-16-1
methylmagnesium bromide

: 917-54-4
methyllithium

: 356073-59-1
1,1-dichloro-2-trifluoromethyl-4-phenylbutan-2-ol

: 2-methyl-5-phenyl-3-trifluoromethylpent-2-ene

Guidance literature:: methylmagnesium bromide; 1,1-dichloro-2-trifluoromethyl-4-phenylbutan-2-ol; In tetrahydrofuran; at -78 ℃; for 1h;

methyllithium; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;
DOI:10.1016/j.tet.2003.09.098