Adenosine, 2'-O-(phenylmethyl)-

Base Information

Chemical Name:Adenosine, 2'-O-(phenylmethyl)-
CAS No.:35638-82-5
Molecular Formula:C17H19N5O4
Molecular Weight:357.369
Hs Code.:
DSSTox Substance ID:DTXSID20461073
Wikidata:Q82285316
Mol file:35638-82-5.mol

Synonyms:Adenosine, 2'-O-(phenylmethyl)-;35638-82-5;(2R,3R,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-(benzyloxy)-2-(hydroxymethyl)tetrahydrofuran-3-ol;SCHEMBL6896076;DTXSID20461073;(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-2-(hydroxymethyl)oxolan-3-ol;(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-phenylmethoxyoxolan-3-ol

Suppliers and Price of Adenosine, 2'-O-(phenylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Adenosine, 2'-O-(phenylmethyl)-

Chemical Property:

Melting Point:150-151.5 °C
Boiling Point:678.5±65.0 °C(Predicted)
PSA：128.54000
Density:1.61±0.1 g/cm3(Predicted)
LogP:0.82570
XLogP3:1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:357.14370410
Heavy Atom Count:26
Complexity:466

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2C(C(OC2N3C=NC4=C(N=CN=C43)N)CO)O
Isomeric SMILES:C1=CC=C(C=C1)CO[C@@H]2[C@@H]([C@H](O[C@H]2N3C=NC4=C(N=CN=C43)N)CO)O

Technology Process of Adenosine, 2'-O-(phenylmethyl)-

There total 10 articles about Adenosine, 2'-O-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 568584-95-2
9-(3-O-benzoyl-2-O-benzyl-β-D-ribofuranosyl)-6-chloropurine

: 35638-82-5
(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-5-(hydroxymethyl) tetrahydrofuran-3-ol

Guidance literature:: With ammonia; In methanol; at 120 ℃;
DOI:10.1081/NCN-120019506

Reference yield:

: 17331-15-6,25816-87-9
(E)-N'-(9-((2S,3R,4S,5R)3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)-N,N-dimethylformimidamide

: 908094-04-2
phenyldiazomethane

: 35638-83-6
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-5-(hydroxymethyl) tetrahydrofuran-3-ol

: 35638-82-5
(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-5-(hydroxymethyl) tetrahydrofuran-3-ol

Guidance literature:: (E)-N'-(9-((2S,3R,4S,5R)3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)-N,N-dimethylformimidamide; phenyldiazomethane; With tin(II) chloride dihdyrate; In methanol; 1,2-dimethoxyethane; at 25 ℃;

With ammonium hydroxide; In methanol; at 25 ℃; for 5h;
DOI:10.1021/jm201000j

Reference yield:

: 228243-48-9
6-chloro-9-(3-O-benzoyl-β-D-ribofuranosyl)purine

: 35638-82-5
(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-5-(hydroxymethyl) tetrahydrofuran-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-azobis(N,N-dimethylformamide); PPh₃

2: NH₃ / methanol

With diamide; ammonia; triphenylphosphine; In methanol; 1: Mitsunobu reaction;
DOI:10.1081/NCN-120022633