(S)-ethyl 4-oxo-1-((R)-1-phenylethyl)piperidine-2-carboxylate

Base Information

Chemical Name:(S)-ethyl 4-oxo-1-((R)-1-phenylethyl)piperidine-2-carboxylate
CAS No.:357154-19-9
Molecular Formula:C₁₆H₂₁NO₃
Molecular Weight:275.348
Hs Code.:
DSSTox Substance ID:DTXSID901174702
Nikkaji Number:J1.797.920E
Mol file:357154-19-9.mol

Synonyms:357154-19-9;(S)-ethyl 4-oxo-1-((R)-1-phenylethyl)piperidine-2-carboxylate;ethyl (2s)-4-oxo-1-[(1r)-1-phenylethyl]piperidine-2-carboxylate;DTXSID901174702;MFCD31803126;AKOS037646865;AS-71264;D85702;Ethyl (2S)-4-oxo-1-[(1R)-1-phenylethyl]-2-piperidinecarboxylate

Suppliers and Price of (S)-ethyl 4-oxo-1-((R)-1-phenylethyl)piperidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of (S)-ethyl 4-oxo-1-((R)-1-phenylethyl)piperidine-2-carboxylate

Chemical Property:

PSA：46.61000
LogP:2.28210
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:275.15214353
Heavy Atom Count:20
Complexity:350

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1CC(=O)CCN1C(C)C2=CC=CC=C2
Isomeric SMILES:CCOC(=O)[C@@H]1CC(=O)CCN1[C@H](C)C2=CC=CC=C2

Technology Process of (S)-ethyl 4-oxo-1-((R)-1-phenylethyl)piperidine-2-carboxylate

There total 4 articles about (S)-ethyl 4-oxo-1-((R)-1-phenylethyl)piperidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(2-Methanesulfonyloxy-ethyl)-2-((R)-1-phenyl-ethyl)-isoxazolidine-3-carboxylic acid ethyl ester

: 357154-18-8
(1'R,2R)-4-oxo-1-(1'-phenylethyl)-piperidine-2-carboxylic acid ethyl ester

: 357154-19-9
(1'R,2S)-4-oxo-1-(1'-phenylethyl)-piperidine-2-carboxylic acid ethyl ester

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile; at 75 ℃; for 1h;
DOI:10.1016/S0040-4020(01)00429-X

Reference yield:

: 924-44-7
glyoxylic acid ethyl ester

: 2627-86-3
(S)-1-phenyl-ethylamine

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 357154-18-8
(1'R,2R)-4-oxo-1-(1'-phenylethyl)-piperidine-2-carboxylic acid ethyl ester

: 357154-19-9
(1'R,2S)-4-oxo-1-(1'-phenylethyl)-piperidine-2-carboxylic acid ethyl ester

Guidance literature:: glyoxylic acid ethyl ester; (S)-1-phenyl-ethylamine; With 3 A molecular sieve; In dichloromethane; toluene; at 0 ℃; for 0.75h;

(R)-1-phenyl-ethyl-amine; With boron trifluoride diethyl etherate; trifluoroacetic acid; In dichloromethane; toluene; at -65 - -30 ℃;
DOI:10.1016/S0040-4020(02)00682-8

Reference yield:

: 357154-20-2
N-[(1R)-phenylethyl]-C-ethoxycarbonylnitrone

: 357154-19-9
(1'R,2S)-4-oxo-1-(1'-phenylethyl)-piperidine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / CHCl₃ / 18 h / Heating

2: pyridine / 4 h / 0 °C

3: 3.29 g / DABCO / acetonitrile / 1 h / 75 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In chloroform; acetonitrile;
DOI:10.1016/S0040-4020(01)00429-X