924-44-7Relevant articles and documents
Friedel-Crafts reactions in water of carbonyl compounds with heteroaromatic compounds
Zhuang, Wei,Jorgensen, Karl Anker
, p. 1336 - 1337 (2002)
The development of Friedel-Crafts reaction in H2O of carbonyl compounds is presented; a series of different heteroaromatic compounds react with ethyl glyoxylate to give the Friedel-Crafts addition adducts in good yields in various H2O solutions.
Asymmetric Catalytic Aza-Diels–Alder/Ring-Closing Cascade Reaction Forming Bicyclic Azaheterocycles by Trienamine Catalysis
Li, Yang,Barl?se, Casper,J?rgensen, Julie,Carlsen, Bj?rn Drei?,J?rgensen, Karl Anker
supporting information, p. 38 - 41 (2017/01/09)
An asymmetric catalytic aza-Diels–Alder/ring-closing cascade reaction between acylhydrazones and in situ formed trienamines is presented. The reaction proceeds through a formal aza-Diels–Alder cycloaddition, followed by a ring-closing reaction forming the hemiaminal ring leading to chiral bicyclic azaheterocycles in moderate to good yield (up to 71 %), good enantio- (up to 92 % ee) and diastereoselectivity (up to >20:1 d.r.). Furthermore, transformations are presented to show the potential application of the formed product.
Synthesis, structure and antiproliferative activity of chiral polyamines based on a 2-azanorbornane skeleton
Kamińska, Karolina,Wojaczyńska, El?bieta,Wietrzyk, Joanna,Turlej, Eliza,B?a?ejczyk, Agnieszka,Wieczorek, Robert
, p. 753 - 758 (2016/07/29)
A series of enantiopure 2-azanorbornane-based amines were prepared via a stereoselective aza-Diels–Alder reaction and further modifications of the obtained cycloadduct. In particular, derivatives containing two bicyclic moieties linked by [Formula presented] fragments were synthesized. Two dimeric derivatives exhibited a significant antiproliferative activity against selected cell lines, comparable to cisplatin in certain cases.
