2-bromo-3-(bromomethyl)quinoline

Base Information

• Chemical Name: 2-bromo-3-(bromomethyl)quinoline
• CAS No.: 35740-83-1
• Molecular Formula: C10H7Br2N
• Molecular Weight: 300.98
• Mol file: 35740-83-1.mol

Synonyms:2-bromo-3-bromomethyl-quinoline;2-Brom-3-brommethylchinolin;2-BROMO-3-(BROMOMETHYL)QUINOLINE;2-bromo-3-bromomethylquinoline;bromo-2-bromomethyl-3-quinoline;

Chemical Property of 2-bromo-3-(bromomethyl)quinoline

Chemical Property:

• Melting Point: 137-138 °C
• Boiling Point: 368.5±27.0 °C(Predicted)
• PKA: -0.50±0.50(Predicted)
• PSA: 12.89000
• Density: 1.852±0.06 g/cm3(Predicted)
• LogP: 3.89220

Purity/Quality:

2-bromo-3-(bromomethyl)quinoline 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-3-(bromomethyl)quinoline

There total 3 articles about 2-bromo-3-(bromomethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-chloro-3-(hydroxymethyl)quinoline (125917-60-4) → 2-bromo-3-bromomethylquinoline (35740-83-1)

Guidance literature:

With phosphorus tribromide; In tetrahydrofuran; at 0 ℃; for 24h;

DOI:10.1039/b614075k

Reference yield: 70.0%

2-chloro-3-quinoline carboxaldehyde (73568-25-9) → 2-bromo-3-bromomethylquinoline (35740-83-1)

Guidance literature:

2-chloro-3-quinoline carboxaldehyde; With sodium tetrahydroborate; In methanol;

With phosphorus tribromide; Further stages.; Heating;

DOI:10.1021/jo0003448

Reference yield:

→ 2-bromo-3-bromomethylquinoline (35740-83-1)

Guidance literature:

Verb. 3 c, NBS;

DOI:10.1021/jo00797a053

upstream raw materials:

2-chloro-3-quinoline carboxaldehyde

2-chloro-3-(hydroxymethyl)quinoline

Downstream raw materials:

camptothecin

N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]trifluoroacetamide

7-(2-methyl-4-oxohex-2-enoyl)-6,8-dihydro-6-(phenylsulfinylmethyl)pyrrolo[3,4-b]quinoline

7-(2-methyl-4-oxohex-2-enoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline