N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]trifluoroacetamide

Base Information

• Chemical Name: N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]trifluoroacetamide
• CAS No.: 620962-74-5
• Molecular Formula: C₂₆H₁₈BrF₃N₂OS₂
• Molecular Weight: 575.473
• Mol file: 620962-74-5.mol

Synonyms:N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]trifluoroacetamide

Chemical Property of N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]trifluoroacetamide

There total 3 articles about N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

trifluoroacetic anhydride (407-25-0) + N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]amine (620962-73-4) → N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]trifluoroacetamide (620962-74-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jo030177m

Reference yield:

2-bromo-3-bromomethylquinoline (35740-83-1) → N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]trifluoroacetamide (620962-74-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / aq. NH₄OH / 120 h / 20 °C

2: 82 percent / MgSO₄ / diethyl ether / 10 h / 20 °C

3: 84 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With ammonium hydroxide; magnesium sulfate; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1021/jo030177m

Reference yield:

C-(2-Bromoquinolin-3-yl)methylamine (292077-58-8) → N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]trifluoroacetamide (620962-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / MgSO₄ / diethyl ether / 10 h / 20 °C

2: 84 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With magnesium sulfate; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1021/jo030177m

upstream raw materials:

trifluoroacetic anhydride

N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]amine

2-bromo-3-bromomethylquinoline

C-(2-Bromoquinolin-3-yl)methylamine

Downstream raw materials:

7-(2-methyl-4-oxohex-2-enoyl)-6,8-dihydro-6-(phenylsulfinylmethyl)pyrrolo[3,4-b]quinoline

7-(2-methyl-4-oxohex-2-enoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline

7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylsulfinylmethyl)pyrrolo[3,4-b]quinoline

7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline