3-phenylimidazo[1,5-a]pyridine

Base Information

• Chemical Name: 3-phenylimidazo[1,5-a]pyridine
• CAS No.: 35854-46-7
• Molecular Formula: C13H10N2
• Molecular Weight: 194.236
• Mol file: 35854-46-7.mol

Synonyms:3-phenylimidazo<1,5-a>pyridine;3-phenylimidazolo<3,4-a>pyridine;Kinome_3407;3-Phenyl-2,3a-diazaindene;

Chemical Property of 3-phenylimidazo[1,5-a]pyridine

Chemical Property:

• Melting Point: 108.0 to 112.0 °C
• Boiling Point: 140°C/2mmHg(lit.)
• PKA: 7.14±0.30(Predicted)
• PSA: 17.30000
• Density: 1.13g/cm3
• LogP: 3.00130

Purity/Quality:

97% ^*data from raw suppliers

3-Phenylimidazo[1,5-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-phenylimidazo[1,5-a]pyridine

There total 29 articles about 3-phenylimidazo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

imidazo[1,5-a]pyridine (274-47-5) + bromobenzene (108-86-1,52753-63-6) → 3-phenylimidazo[1,5-a]pyridine (35854-46-7)

Guidance literature:

With tetrabutylammonium acetate; palladium diacetate; triphenylphosphine; In toluene; at 100 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1246/cl.2011.1053

Reference yield: 95.0%

2-(Aminomethyl)pyridine (3731-51-9) + benzoic acid (65-85-0,8013-63-6) → 3-phenylimidazo[1,5-a]pyridine (35854-46-7)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In acetic acid butyl ester; ethyl acetate; at 160 ℃; for 0.75h; Microwave irradiation; Sealed tube;

DOI:10.1016/j.dyepig.2019.107713

Reference yield: 92.0%

N-benzyl-2-pyridinecarboxamide (18904-38-6) → 3-phenylimidazo[1,5-a]pyridine (35854-46-7)

Guidance literature:

With trichlorophosphate; at 150 ℃; for 0.75h; Microwave irradiation;

DOI:10.1016/j.tetlet.2009.10.137

upstream raw materials:

N-((pyridin-2-yl)methyl)benzamide

N-benzyl-2-pyridinecarboxamide

N-(2-pyridyl)methyl benzenecarbothioamide

2-(Aminomethyl)pyridine

Downstream raw materials:

3-(2’-pyridyl)-5-phenyl-1,2,4-oxadiazole

1-nitro-3-phenyl-imidazo[1,5-a]pyridine

2-isopropyl-3-phenylimidazo[1,5-a]pyridinium iodide

1-chloro-3-phenylimidazo[1,5-a]pyridine