N-benzylpyridine-2-carboxamide

Base Information

• Chemical Name: N-benzylpyridine-2-carboxamide
• CAS No.: 18904-38-6
• Molecular Formula: C13H12N2O
• Molecular Weight: 212.251
• DSSTox Substance ID: DTXSID00350734
• Nikkaji Number: J1.485.134H
• Wikidata: Q82126824

Synonyms:N-benzylpyridine-2-carboxamide;N-Benzylpicolinamide;18904-38-6;2-Pyridinecarboxamide, N-(phenylmethyl)-;starbld0037443;Cambridge id 5100084;Oprea1_054854;Oprea1_858379;CBDivE_000043;2-(N-benzylcarbamoyl)pyridine;n-benzyl-2-pyridinecarboxamide;SCHEMBL3083971;DTXSID00350734;STK391105;AKOS000629707;CS-0362496;F70940;AB00073525-01;Z27749501

Chemical Property of N-benzylpyridine-2-carboxamide

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 212.094963011
• Heavy Atom Count: 16
• Complexity: 224

Purity/Quality:

97% purity ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CNC(=O)C2=CC=CC=N2

Technology Process of N-benzylpyridine-2-carboxamide

There total 29 articles about N-benzylpyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Picolinic acid (98-98-6) + benzylamine (100-46-9) → N-benzyl-2-pyridinecarboxamide (18904-38-6)

Guidance literature:

With tetrachloromethane; Bis(p-nitrophenyl) phosphate; 3-Methyl-1-phenyl-2-phospholene 1-oxide; In toluene; at 110 ℃; for 20h; Green chemistry;

DOI:10.1039/c7ob01510k

Reference yield: 99.0%

ethyl-2-picolinate (2524-52-9,1228273-66-2) + benzylamine (100-46-9) → N-benzyl-2-pyridinecarboxamide (18904-38-6)

Guidance literature:

With iron(III) chloride; In neat (no solvent); at 80 ℃; Sealed tube;

DOI:10.3390/molecules25051040

Reference yield: 99.0%

methyl pyridine-2-carboxylate (2459-07-6,260998-83-2) + benzylamine (100-46-9) → N-benzyl-2-pyridinecarboxamide (18904-38-6)

Guidance literature:

With magnesium chloride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/S0040-4039(01)00079-X

upstream raw materials:

ethyl-2-picolinate

benzylamine

2-Picolinic acid

C₁₈H₁₃N₃O₂

Downstream raw materials:

Pyridine-2-carboxylic acid (2-hydroxy-1,2,2-triphenyl-ethyl)-amide

Pyridine-2-carboxylic acid [(1-hydroxy-cyclohexyl)-phenyl-methyl]-amide

6-Benzyl-5-hydroxy-5-p-tolyl-5,6-dihydro-pyrrolo[3,4-b]pyridin-7-one

6-Benzyl-5-(4-chloro-phenyl)-5-hydroxy-5,6-dihydro-pyrrolo[3,4-b]pyridin-7-one

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