ethyl 2-methyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 2-methyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate
• CAS No.: 35929-95-4
• Molecular Formula: C22H18N2O5
• Molecular Weight: 390.395
• Mol file: 35929-95-4.mol

Synonyms:2-methyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylic acid ethyl ester;2-Methyl-4-(4-nitro-phenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylic acid ethyl ester;3-Ethoxycarbonyl-2-methyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine;ethyl 2-methyl-5-oxo-4-(4-nitrophenyl)-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate;2-Methyl-3-ethoxycarbonyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine;3-ethoxycarbonyl-4-(4-nitrophenyl)-5-oxo-1,4-dinitroindeno<1,2-b>pyridine;

Chemical Property of ethyl 2-methyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate

Chemical Property:

• Melting Point: 216 - 218 °C (ethanol)
• PSA: 101.22000
• LogP: 4.57830

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-methyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate

There total 4 articles about ethyl 2-methyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1H-indene-1,3(2H)-dione (606-23-5) + ethyl acetoacetate (141-97-9) + 4-nitrobenzaldehdye (555-16-8) → 2-Methyl-3-ethoxycarbonyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine (35929-95-4)

Guidance literature:

With ammonium acetate; ytterbium(III) triflate; In ethanol; at 20 ℃; for 0.5h; Sonication;

Reference yield:

1H-indene-1,3(2H)-dione (606-23-5) → 2-Methyl-3-ethoxycarbonyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine (35929-95-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 130 - 140 °C

2: acetic acid

With acetic acid;

DOI:10.1039/jr9490002134

Reference yield:

4-nitrobenzaldehdye (555-16-8) → 2-Methyl-3-ethoxycarbonyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine (35929-95-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 130 - 140 °C

2: acetic acid

With acetic acid;

DOI:10.1039/jr9490002134

upstream raw materials:

2-(p-nitrobenzylidene)indan-1,3-dione

ethyl aminocrotonate

1H-indene-1,3(2H)-dione

4-nitrobenzaldehdye

Downstream raw materials:

2-methyl-4-(4-nitro-phenyl)-5-oxo-5H-indeno[1,2-b]pyridine-3-carboxylic acid ethyl ester

1,2-Dimethyl-3-ethoxycarbonyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine

2,4a-Dimethyl-4-(4-nitro-phenyl)-5-oxo-4a,5-dihydro-4H-indeno[1,2-b]pyridine-3-carboxylic acid ethyl ester

2-Methyl-4-(4-nitro-phenyl)-5-thioxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylic acid ethyl ester