Ethyl 3-aminocrotonate

Base Information

• Chemical Name: Ethyl 3-aminocrotonate
• CAS No.: 626-34-6
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.159
• Hs Code.: 29224999
• Mol file: 626-34-6.mol

Synonyms:2-butenoic acid, 3-amino-, ethyl ester;

Chemical Property of Ethyl 3-aminocrotonate

Chemical Property:

• Appearance/Colour: liquid
• Vapor Pressure: 0.173mmHg at 25°C
• Melting Point: 33-35 °C(lit.)
• Refractive Index: 1.4990
• Boiling Point: 212.5 °C at 760 mmHg
• PKA: 5.32±0.70(Predicted)
• Flash Point: 97.2 °C
• PSA: 52.32000
• Density: 1.007 g/cm³
• LogP: 1.11230
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Air & Moisture Sensitive & Hygro
• Water Solubility.: Soluble in water (26 g/L) (25°C).

Purity/Quality:

99.9% ^*data from raw suppliers

Ethyl 3-aminocrotonate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Ethyl 3-aminocrotonate, is used as an intermediate in organic synthesis. It is also used as an active ingredient in pharmaceutical synthesis and feed auxiliary agent. It is also used as an active pharmaceutical intermediate.

Technology Process of Ethyl 3-aminocrotonate

There total 32 articles about Ethyl 3-aminocrotonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl acetoacetate (141-97-9) → ethyl aminocrotonate (626-34-6,7318-00-5,41867-20-3)

Guidance literature:

With ammonium acetate; In ethanol; at 20 ℃; for 6h;

DOI:10.1016/j.crci.2010.09.009

Reference yield: 65.0%

4-chloro-2H-chromene-3-carboxaldehyde (14063-82-2) + ethyl acetoacetate (141-97-9) → diethyl-4-(4-chloro-2H-chromen-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate + ethyl aminocrotonate (626-34-6,7318-00-5,41867-20-3) + ethyl 2-methyl-5H-chromeno[3,4-c]pyridine-1-carboxylate

Guidance literature:

With ammonium acetate; In methanol; at 20 ℃;

DOI:10.1080/00397911.2019.1631850

Reference yield: 28.0%

ethyl acetoacetate (141-97-9) + 4-methoxy-benzaldehyde (123-11-5) → C14H17NO3 (1309978-19-5) + ethyl aminocrotonate (626-34-6,7318-00-5,41867-20-3)

Guidance literature:

With ammonium acetate; In ethanol; at 20 ℃; for 6h;

DOI:10.1016/j.crci.2010.09.009

upstream raw materials:

Ethyl 2-butynoate

ethyl acetoacetate

E-Ethyl β-chlorocrotonate

ethanol

Downstream raw materials:

ethyl (Z)-β-acetylaminobut-2-enoate

methyl (E)-3-acetamido-2-butenoate

(E)-ethyl 2-acetyl-3-aminobut-2-enoate

2-methylpyrimido[1,2-a]benzimidazol-4(1H)-one

Refernces

• 1、 -. "HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF". Paragraph 0859-0860. . Retrieved 2021/02/25.
• 2、 Hariprasad, K. S.,Prakasham, R. S.,Praveena, G.,Raju, B. China,Ramya, S.,Suchitra Rani, K.,Tiwari, A. K.,Zehra, A.. "Synthesis and Biological Activities of Nicotinaldehyde Based 1,4-Dihydropyridinedicarboxylates". . p. 1335 - 1340. Retrieved 2021/12/23.