(1S,2R)-N-BOC-1-AMINO-2-PHENYLCYCLOPROPANECARBOXYLIC ACID

Base Information

• Chemical Name: (1S,2R)-N-BOC-1-AMINO-2-PHENYLCYCLOPROPANECARBOXYLIC ACID
• CAS No.: 151910-11-1
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Hs Code.: 2922498590
• Mol file: 151910-11-1.mol

Synonyms:Cyclopropanecarboxylicacid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, (1S-trans)-;

Chemical Property of (1S,2R)-N-BOC-1-AMINO-2-PHENYLCYCLOPROPANECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 6.78E-09mmHg at 25°C
• Melting Point: 89-91 °C
• Refractive Index: 1.564
• Boiling Point: 450.3 °C at 760 mmHg
• Flash Point: 226.1 °C
• PSA: 75.63000
• Density: 1.22 g/cm³
• LogP: 2.91290

Purity/Quality:

99%, ^*data from raw suppliers

(1S,2R)-N-Boc-1-amino-2-phenylcyclopropanecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,2R)-N-BOC-1-AMINO-2-PHENYLCYCLOPROPANECARBOXYLIC ACID

There total 11 articles about (1S,2R)-N-BOC-1-AMINO-2-PHENYLCYCLOPROPANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1S,2R)-1-(tert-butoxycarbonylamino)-2-phenylcyclopropanecarboxylic 4-nitrobenzoic anhydride → (1S,2R)-1--2-phenylcyclopropane-1-carboxylic acid (151910-11-1)

Guidance literature:

With sodium hydroxide; In methanol; water; at 60 ℃; for 2h;

Reference yield: 97.0%

(1S,2R)-(E)-methyl 1-carbonyl>amino>-2-phenylcyclopropane-1-carboxylate (151910-10-0) → (1S,2R)-1--2-phenylcyclopropane-1-carboxylic acid (151910-11-1)

Guidance literature:

With lithium hydroxide; In methanol; water; for 2.5h; Heating;

DOI:10.1021/jo00076a077

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (1S,2R)-1--2-phenylcyclopropane-1-carboxylic acid (151910-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-methyl-propan-2-ol; hexane / Heating

2: aq. LiOH / methanol / Heating

With lithium hydroxide; In methanol; hexane; tert-butyl alcohol;

DOI:10.1021/ja9604931

upstream raw materials:

(1S,2R)-(E)-methyl 1-carbonyl>amino>-2-phenylcyclopropane-1-carboxylate

di-tert-butyl dicarbonate

methyl (1S,2R)-1-amino-2-phenylcyclopropanecarboxylate

1-(methoxycarbonyl)-2-phenylcyclopropanecarboxylic acid

Downstream raw materials:

(1S,2R)-1-amino-2-phenylcyclopropanecarboxamide trifluoroacetate

(1S,2R)-(E)-(+)-1-amino-2-phenyl-1-cyclopropane-1-carboxylic acid hydrochloride

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