2-Bromo-5-methoxybenzaldehyde

Base Information

• Chemical Name: 2-Bromo-5-methoxybenzaldehyde
• CAS No.: 7507-86-0
• Molecular Formula: C8H7BrO2
• Molecular Weight: 215.046
• Hs Code.: 2913000090
• Mol file: 7507-86-0.mol

Synonyms:3-Methoxy-6-bromobenzaldehyde;NSC 401439;

Chemical Property of 2-Bromo-5-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 71-76 oC
• Refractive Index: 1.585
• Boiling Point: 284.3 °C at 760 mmHg
• Flash Point: 125.7 °C
• PSA: 26.30000
• Density: 1.522 g/cm³
• LogP: 2.27020
• Storage Temp.: Room temperature.
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Bromo-5-methoxybenzaldehyde is used in preparation of Benzimidazole Quinolines. Also, used in preparation of Cyclopentenes, Polycycles, Benzocarbocycles/N-Heterocycle derivatives.

Technology Process of 2-Bromo-5-methoxybenzaldehyde

There total 19 articles about 2-Bromo-5-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-5-hydroxybenzaldehyde (2973-80-0) + methyl iodide (74-88-4) → 2-bromo-5-methoxy-benzaldehyde (7507-86-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 60h;

Reference yield: 99.0%

3-methoxy-benzaldehyde (591-31-1) → 2-bromo-5-methoxy-benzaldehyde (7507-86-0)

Guidance literature:

With bromine; In acetic acid; at 25 ℃; Inert atmosphere;

DOI:10.1002/anie.201002264

Reference yield: 99.0%

2-Bromo-5-methoxybenzyl alcohol (150192-39-5) → 2-bromo-5-methoxy-benzaldehyde (7507-86-0)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃;

DOI:10.1039/c2dt32422a

upstream raw materials:

3-methoxy-benzaldehyde

2-bromo-5-hydroxybenzaldehyde

methyl iodide

3-methoxybenzyl alcohol

Downstream raw materials:

5,10,15,20-tetrakis(2-bromo-5-methoxyphenyl)porphyrin

9-(2-bromo-5-methoxybenzylidene)fluorene

1-bromo-5-dimethoxy-2-vinylbenzene

methyl 3-(2-formyl-4-methoxyphenoxy)benzoate

Refernces

• 1、 -. "COMPOUNDS AND COMPOSITIONS FOR USE IN TREATING SKIN DISORDERS". Paragraph 0592; 0620-0622. . Retrieved 2021/08/06.
• 2、 Slack, Eric D.,Seupel, Raina,Aue, Donald H.,Bringmann, Gerhard,Lipshutz, Bruce H.. "Atroposelective Total Synthesis of the Fourfold ortho-Substituted Naphthyltetrahydroisoquinoline Biaryl O,N-Dimethylhamatine". supporting information. p. 14237 - 14245. Retrieved 2019/11/11.