1-Benzyl-4,7-dimethoxy-1H-benzimidazole

Base Information

Chemical Name:1-Benzyl-4,7-dimethoxy-1H-benzimidazole
CAS No.:36098-02-9
Molecular Formula:C16H16N2O2
Molecular Weight:268.315
Hs Code.:
DSSTox Substance ID:DTXSID90513018
Wikidata:Q82372531

Synonyms:36098-02-9;1-Benzyl-4,7-dimethoxy-1H-benzimidazole;DTXSID90513018

Suppliers and Price of 1-Benzyl-4,7-dimethoxy-1H-benzimidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Benzyl-4,7-dimethoxy-1H-benzimidazole

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:268.121177757
Heavy Atom Count:20
Complexity:307

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C2C(=C(C=C1)OC)N(C=N2)CC3=CC=CC=C3

Technology Process of 1-Benzyl-4,7-dimethoxy-1H-benzimidazole

There total 6 articles about 1-Benzyl-4,7-dimethoxy-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 7711-50-4
4,7-dimethoxybenzimidazole

: 100-39-0
benzyl bromide

: 36098-02-9
1-benzyl-4,7-dimethoxy-1H-benzimidazole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 12h;
DOI:10.1002/ejoc.200400803

Reference yield:

: 7711-50-4
4,7-dimethoxybenzimidazole

: 36098-02-9
1-benzyl-4,7-dimethoxy-1H-benzimidazole

Guidance literature:: 4,7-dimethoxybenzimidazole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

benzyl halide; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/S0960-894X(02)00064-1

Reference yield:

: 150-78-7
1,4-dimethoxybezene

: 36098-02-9
1-benzyl-4,7-dimethoxy-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: conc. HNO₃ / acetic anhydride / 0 °C

1.2: Sn; conc. HCl / 100 °C

2.1: 4.75 g / 5.5 h / Heating

3.1: NaH / dimethylformamide / 0.25 h

3.2: 1.12 g / dimethylformamide / 12 h

With nitric acid; sodium hydride; In acetic anhydride; N,N-dimethyl-formamide; 2.1: Phillips cyclization;
DOI:10.1515/HC.2006.12.2.111