tert-butyl [(2S,3S)-6-{[(2S,3S)-5-{[(2S)-1-{[3-(aminomethyl)benzyl]amino}-4-methyl-1-oxopentan-2-yl]amino}-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino}-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate (non-preferred name)

Base Information

Chemical Name:tert-butyl [(2S,3S)-6-{[(2S,3S)-5-{[(2S)-1-{[3-(aminomethyl)benzyl]amino}-4-methyl-1-oxopentan-2-yl]amino}-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino}-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate (non-preferred name)
CAS No.:124339-32-8
Molecular Formula:C₄₂H₆₅N₅O₇
Molecular Weight:752.007
Hs Code.:
Mol file:124339-32-8.mol

tert-butyl [(2S,3S)-6-{[(2S,3S)-5-{[(2S)-1-{[3-(aminomethyl)benzyl]amino}-4-methyl-1-oxopentan-2-yl]amino}-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino}-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate (non-preferred name)

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl [(2S,3S)-6-{[(2S,3S)-5-{[(2S)-1-{[3-(aminomethyl)benzyl]amino}-4-methyl-1-oxopentan-2-yl]amino}-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino}-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate (non-preferred name)

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:993.2°C at 760 mmHg
Flash Point:554.5°C
Density:1.14g/cm³

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl [(2S,3S)-6-{[(2S,3S)-5-{[(2S)-1-{[3-(aminomethyl)benzyl]amino}-4-methyl-1-oxopentan-2-yl]amino}-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino}-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate (non-preferred name)

There total 6 articles about tert-butyl [(2S,3S)-6-{[(2S,3S)-5-{[(2S)-1-{[3-(aminomethyl)benzyl]amino}-4-methyl-1-oxopentan-2-yl]amino}-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino}-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118405-01-9,124338-98-3,124339-26-0
Boc-PheΨACHPA-Leu-NHCH2-m-Ph-CH2NHZ

: 118405-04-2,124339-02-2,124339-32-8,151282-85-8
Boc-PheΨGly-ACHPA-Leu-NHCH2-m-Ph-CH2NH2

Guidance literature:: With hydrogen; nickel; In methanol; at 24 ℃; under 2585.7 Torr;
DOI:10.1021/jm00164a058

Reference yield:

: 99113-32-3,99113-34-5,118386-98-4
(2E,4R,S,5S)-5-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-6-phenyl-2-hexenoic acid

: 118405-04-2,124339-02-2,124339-32-8,151282-85-8
Boc-PheΨGly-ACHPA-Leu-NHCH2-m-Ph-CH2NH2

Guidance literature:: Multi-step reaction with 2 steps

1: HOBT/DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) room temp.

2: H₂ / Raney Ni / methanol / 24 °C / 2585.7 Torr

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; nickel; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a058

Reference yield:

: 118457-05-9
Methyl (S)-5-<(tert-butoxycarbonyl)amino>-6-phenyl-(E)-3-hexenoate

: 118405-04-2,124339-02-2,124339-32-8,151282-85-8
Boc-PheΨGly-ACHPA-Leu-NHCH2-m-Ph-CH2NH2

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 72 h / Ambient temperature

2: 1.1 g / 1 N NaOH / methanol / 2 h / Ambient temperature

3: HOBT/DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) room temp.

4: H₂ / Raney Ni / methanol / 24 °C / 2585.7 Torr

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; nickel; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a058