118457-05-9Relevant academic research and scientific papers
Kinetic deconjugation: A gateway to the synthesis of Xxx-Gly (E)-alkene dipeptide isosteres
Proteau-Gagné, Arnaud,Nadon, Jean-Franois,Bernard, Sylvain,Guérin, Brigitte,Gendron, Louis,Dory, Yves L.
, p. 6603 - 6605 (2012/02/03)
A new method for the preparation of Xxx-Gly (E)-alkene dipeptide isosteres (EADIs), using LDA deprotonation followed by 1 N HCl quench, was explored. The method, named kinetic deconjugation, enabled the synthesis of Tyr-Gly, Gly-Gly, Ser-Gly, Pro-Gly, and
Stereoselective Epoxidation of Phe-Gly and Phe-Phe Vinyl Isosteres
Jenmalm, Annika,Berts, Wei,Li, Yi-Lin,Luthman, Kristina,Csoeregh, Ingeborg,Hacksell, Uli
, p. 1139 - 1148 (2007/10/02)
Novel Phe-Gly and Phe-Phe isosteres have been synthesized.Vinylic isosteres of Phe-Gly and Phe-Phe were prepared by facile Julia reactions, and the resulting stereoisomers were isolated and epoxidized (m-chloroperbenzoic acid).Observed stereoselectivities
Novel L-Phe-Gly mimetics
Li, Yi-Lin
, p. 4487 - 4490 (2007/10/02)
The syntheses of some novel dipeptidomimetics of potential biological interest are described. The reactions started from the vinyl isostere of Phe-Gly and were performed in high yields. Stereochemically pure products were isolated.
A SIMPLE SYNTHESIS OF ΨGly DIPEPTIDE ISOSTERES VIA REDUCTIVE ELIMINATION OF γ-OXYGENATED α,β-ENOATES WITH ALKENYLCOPPER REAGENTS
Fujii, Nobutaka,Habashita, Hiromu,Shigemori, Noriko,Otaka, Akira,Ibuka, Toshiro,et al.
, p. 4969 - 4972 (2007/10/02)
Readily available protected forms of δ-amino-γ-mesyloxy-α,β-enoates can be converted to protected dipeptide isosters, ΨGly, in high yields by reduction with alkenylcopper reagents. Keywords: dipeptide isosters; ΨGly; γ-mesyloxy-α,β-eno
Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites
Kaltenbronn,Hudspeth,Lunney,Michniewicz,Nicolaides,Repine,Roark,Stier,Tinney,Woo,Essenburg
, p. 838 - 845 (2007/10/02)
Renin inhibitors having 13 different isosteres connecting the P3 and P2 positions have been prepared. Synthetic routes and in vitro activity exhibited by these compounds are discussed. The two most potent compounds, 47 and 48, contai
