10.1039/b904615a
The study focuses on the oxidation of Ni(II) N-confused porphyrins (NCPs) using azo radical initiators, which leads to an unexpected intramolecular nucleophilic substitution reaction via a proposed Ni(III) NCP intermediate. The main chemicals used in the study include Ni(II) NCPs, azo radical initiators such as AIBN (2,2'-azobisisobutyronitrile), dimethyl 2,2'-azobis(2-methylpropionate), and diethyl 2,2'-azobis(2-methylpropionate). These chemicals serve the purpose of oxidizing Ni(II) NCPs to Ni(III) NCPs, which are key intermediates in many chemical reactions and have biological significance in enzyme-catalyzed reactions. The study aims to understand the role of nickel in these enzymes and to model nickel biosites synthetically, which could help in investigating the precise function of the nickel ion in biological processes. The research also explores the stability and reactivity of Ni(III) NCPs, which are rare and usually unstable, and the results provide insights into the oxidative chemistry of Ni(II) porphyrins and the potential applications of Ni(III) NCPs in biomimetic nickel chemistry.
