3,5-Pyridinedicarboxylic acid, 4-(chloromethyl)-1,4-dihydro-2,6-dimethyl-, diethyl ester

Base Information

• Chemical Name: 3,5-Pyridinedicarboxylic acid, 4-(chloromethyl)-1,4-dihydro-2,6-dimethyl-, diethyl ester
• CAS No.: 3613-34-1
• Molecular Formula: C14H20ClNO4
• Molecular Weight: 301.77
• Hs Code.: 2933399090
• Mol file: 3613-34-1.mol

Synonyms:DIETHYL-4-CHLOROMETHYL-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINE DICARBOXYLATE;4-Chlormethyl-1,4-dihydro-2,6-lutidin-3,5-dicarbonsaeure-diethylester;Diethyl-4-chlormethyl-1,4-diyhdro-2,6-dimethylpyridin-3,5-dicarboxylat;4-Chlormethyl-2,6-dimethyl-1,4-dihydro-pyridin-3,5-dicarbonsaeure-diaethylester;2,6-Dimethyl-4-chlormethyl-3,5-bis-ethoxycarbonyl-1,4-dihydropyridin;4-chloromethyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester;4-Chlormethyl-2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydro-pyridin;

Chemical Property of 3,5-Pyridinedicarboxylic acid, 4-(chloromethyl)-1,4-dihydro-2,6-dimethyl-, diethyl ester

Chemical Property:

• PSA: 64.63000
• LogP: 2.44760

Purity/Quality:

95% ^*data from raw suppliers

DIETHYL-4-CHLOROMETHYL-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINE DICARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Pyridinedicarboxylic acid, 4-(chloromethyl)-1,4-dihydro-2,6-dimethyl-, diethyl ester

There total 3 articles about 3,5-Pyridinedicarboxylic acid, 4-(chloromethyl)-1,4-dihydro-2,6-dimethyl-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

2-chloroethanal (107-20-0) + ethyl acetoacetate (141-97-9) → diethyl 4-chloromethyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (3613-34-1)

Guidance literature:

With ammonium hydroxide; ammonium acetate; In ethanol; at 70 ℃; for 8h;

DOI:10.1021/acs.joc.9b02323

Reference yield:

1,2-dichloro-2-ethoxyethane (623-46-1) + ethyl aminocrotonate (626-34-6,7318-00-5,41867-20-3) → diethyl 4-chloromethyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (3613-34-1)

Guidance literature:

With benzene;

Reference yield:

→ diethyl 4-chloromethyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (3613-34-1)

Guidance literature:

α-Amino-crotonsaeure-ethylester, 1,2-Dichlor-ethyl-ethyl-ether, Bzl.;

DOI:10.1039/jr9630004819

upstream raw materials:

1,2-dichloro-2-ethoxyethane

ethyl aminocrotonate

2-chloroethanal

ethyl acetoacetate

Downstream raw materials:

4-cyano-2,5-dimethyl-pyrrole-3-carboxylic acid ethyl ester

4-cyano-2,7-dimethyl-4,5-dihydro-1H-azepine-3,6-dicarboxylic acid diethyl ester

4-(4-fluorophenyl)-4-oxo-n-butyl chloride