Technology Process of Butanedioic acid, 2-hydroxy-3-(phenylmethyl)-, bis(1-methylethyl) ester,
(2S,3R)-
There total 4 articles about Butanedioic acid, 2-hydroxy-3-(phenylmethyl)-, bis(1-methylethyl) ester,
(2S,3R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2S-Hydroxybutan-1,4-dioic acid diisopropyl ester;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 0.5h;
benzyl bromide;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 16h;
With
water; ammonium chloride;
In
tetrahydrofuran;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) thionyl chloride, 2.) NaIO4, RuCl3*3H2O / 1.) CCl4, reflux, 30 min, 2.) CH3CN/H2O, room temperature, 60 min
2: 1.) Li2CuCl4, 2.) 20 percent aq. H2SO4 / 1.) THF, -78 deg C, 2 h, 2.) ether, 25 deg C, 12 h
With
ruthenium trichloride; sodium periodate; thionyl chloride; dilithium tetrachlorocuprate; sulfuric acid;
DOI:10.1021/ja00230a045
- Guidance literature:
-
With
dilithium tetrachlorocuprate; sulfuric acid;
Yield given. Multistep reaction;
1.) THF, -78 deg C, 2 h, 2.) ether, 25 deg C, 12 h;
DOI:10.1021/ja00230a045
