Carbamic acid, [(1S,2S,4R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methyl-5-[[(1S)-2- methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]amino]-1-(2-methylprop yl)-5-oxopentyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S,2S,4R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methyl-5-[[(1S)-2- methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]amino]-1-(2-methylprop yl)-5-oxopentyl]-, 1,1-dimethylethyl ester
CAS No.:364635-77-8
Molecular Formula:C33H59N3O5Si
Molecular Weight:605.934
Hs Code.:
Mol file:364635-77-8.mol

Carbamic acid,
[(1S,2S,4R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methyl-5-[[(1S)-2-
methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]amino]-1-(2-methylprop
yl)-5-oxopentyl]-, 1,1-dimethylethyl ester

Synonyms:

Suppliers and Price of Carbamic acid, [(1S,2S,4R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methyl-5-[[(1S)-2- methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]amino]-1-(2-methylprop yl)-5-oxopentyl]-, 1,1-dimethylethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(1S,2S,4R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methyl-5-[[(1S)-2- methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]amino]-1-(2-methylprop yl)-5-oxopentyl]-, 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of Carbamic acid, [(1S,2S,4R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methyl-5-[[(1S)-2- methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]amino]-1-(2-methylprop yl)-5-oxopentyl]-, 1,1-dimethylethyl ester

There total 9 articles about Carbamic acid, [(1S,2S,4R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methyl-5-[[(1S)-2- methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]amino]-1-(2-methylprop yl)-5-oxopentyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 106566-02-3,120369-25-7,144902-31-8
L-valine benzylamide

: 271601-65-1
(2R,4S,5S)-5-[(tert-butyloxycarbonyl)amino]-4-[(tert-butyldimethylsilyl)oxy]-2,7-dimethyloctanoic acid

: 364635-77-8
tert-butyl (1S,2S,4R)-5-({(1S)-1-[(benzylamino)carbonyl]-2-methylpropyl}amino)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-isobutyl-4-methyl-5-oxopentylcarbamate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 23 ℃;
DOI:10.1021/ja058636j

Reference yield: 95.0%

: 364635-77-8
tert-butyl (1S,2S,4R)-5-({(1S)-1-[(benzylamino)carbonyl]-2-methylpropyl}amino)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-isobutyl-4-methyl-5-oxopentylcarbamate

Guidance literature:

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 364635-77-8
tert-butyl (1S,2S,4R)-5-({(1S)-1-[(benzylamino)carbonyl]-2-methylpropyl}amino)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-isobutyl-4-methyl-5-oxopentylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / HOBt; EDC; diisopropylethylamine / CH₂Cl₂; dimethylformamide / 0 - 23 °C

2: 297 mg / TFA / CH₂Cl₂ / 0.5 h / 23 °C

3: 95 percent / EDC; HOBt; diisopropylethylamine / dimethylformamide / 0 - 23 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0101803