Octanamide, 5-amino-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,7-dimethyl-N-[(1S)-2- methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-, (2R,4S,5S)-

Base Information

Chemical Name:Octanamide, 5-amino-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,7-dimethyl-N-[(1S)-2- methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-, (2R,4S,5S)-
CAS No.:836612-92-1
Molecular Formula:C₂₈H₅₁N₃O₃Si
Molecular Weight:505.817
Hs Code.:

Octanamide,
5-amino-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,7-dimethyl-N-[(1S)-2-
methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-, (2R,4S,5S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Octanamide, 5-amino-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,7-dimethyl-N-[(1S)-2- methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-, (2R,4S,5S)-

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Technology Process of Octanamide, 5-amino-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,7-dimethyl-N-[(1S)-2- methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-, (2R,4S,5S)-

There total 1 articles about Octanamide, 5-amino-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,7-dimethyl-N-[(1S)-2- methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-, (2R,4S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 364635-77-8
tert-butyl (1S,2S,4R)-5-({(1S)-1-[(benzylamino)carbonyl]-2-methylpropyl}amino)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-isobutyl-4-methyl-5-oxopentylcarbamate

: 836612-92-1
(2R,4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-octanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2004.10.084

Reference yield:

: 836612-92-1
(2R,4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-octanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

: (4S,7S)-4-Isopropyl-2,5,9-trioxo-1-oxa-3,6,10-triaza-cyclotetradecane-7-carboxylic acid [(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-hydroxy-1-isobutyl-pentyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; diisopropylethylamine

2: H₂ / Pd/C

3: aq. HF / tetrahydrofuran

With hydrogen fluoride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2004.10.084

Reference yield:

: 836612-92-1
(2R,4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-octanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

: (4S,7S)-4-Isopropyl-2,5,9-trioxo-1-oxa-3,6,10-triaza-cyclopentadecane-7-carboxylic acid [(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-hydroxy-1-isobutyl-pentyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; diisopropylethylamine

2: H₂ / Pd/C

3: aq. HF / tetrahydrofuran

With hydrogen fluoride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2004.10.084