Methanesulfonic acid, trifluoro-, 3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-quinolin yl ester

Base Information

Chemical Name:Methanesulfonic acid, trifluoro-, 3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-quinolin yl ester
CAS No.:364793-73-7
Molecular Formula:C19H12Cl2F3N3O5S
Molecular Weight:522.289
Hs Code.:
Mol file:364793-73-7.mol

Synonyms:

Suppliers and Price of Methanesulfonic acid, trifluoro-, 3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-quinolin yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid, trifluoro-, 3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-quinolin yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Methanesulfonic acid, trifluoro-, 3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-quinolin yl ester

There total 10 articles about Methanesulfonic acid, trifluoro-, 3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-quinolin yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 4-(2,4-dichloro-5-methoxyphenylamino)-7-hydroxy-6-methoxyquinoline-3-carbonitrile

: 364793-73-7
3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxyquinolin-7-yl trifluoromethanesulfonate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; Cooling with ice; Inert atmosphere;

Reference yield:

: 364793-72-6
(4-chloro-3-cyano-6-methoxy-7-quinolyl)trifluoromethanesulfonate

: 364793-73-7
3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxyquinolin-7-yl trifluoromethanesulfonate

Guidance literature:: In 1-ethoxyethanol; pyridine hydrochloride;

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 364793-73-7
3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxyquinolin-7-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: K₂CO₃ / dimethylformamide

2.1: HNO₃; AcOH

3.1: BCl₃ / CH₂Cl₂

4.1: pyridine / CH₂Cl₂

5.1: Fe; aq. NH₄Cl / methanol

6.2: nBuLi / tetrahydrofuran

7.1: POCl₃ / Heating

8.1: pyridine hydrochloride / 2-ethoxy-ethanol

With pyridine; nitric acid; pyridine hydrochloride; boron trichloride; iron; potassium carbonate; ammonium chloride; acetic acid; trichlorophosphate; In methanol; 2-ethoxy-ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00577-2