4-chloro-3-cyano-6-methoxyquinolin-7-yl trifluoromethanesulfonate

Base Information

• Chemical Name: 4-chloro-3-cyano-6-methoxyquinolin-7-yl trifluoromethanesulfonate
• CAS No.: 364793-72-6
• Molecular Formula: C₁₂H₆ClF₃N₂O₄S
• Molecular Weight: 366.705
• Mol file: 364793-72-6.mol

Synonyms:(4-chloro-3-cyano-6-methoxy-7-quinolyl)trifluoromethanesulfonate

Chemical Property of 4-chloro-3-cyano-6-methoxyquinolin-7-yl trifluoromethanesulfonate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-3-cyano-6-methoxyquinolin-7-yl trifluoromethanesulfonate

There total 7 articles about 4-chloro-3-cyano-6-methoxyquinolin-7-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyano-6-methoxy-4-oxo-1,4-dihydro-7-quinolinyl trifluoromethanesulfonate (364793-71-5) → (4-chloro-3-cyano-6-methoxy-7-quinolyl)trifluoromethanesulfonate (364793-72-6)

Guidance literature:

With trichlorophosphate; Heating;

DOI:10.1016/S0960-894X(02)00577-2

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → (4-chloro-3-cyano-6-methoxy-7-quinolyl)trifluoromethanesulfonate (364793-72-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: K₂CO₃ / dimethylformamide

2.1: HNO₃; AcOH

3.1: BCl₃ / CH₂Cl₂

4.1: pyridine / CH₂Cl₂

5.1: Fe; aq. NH₄Cl / methanol

6.2: nBuLi / tetrahydrofuran

7.1: POCl₃ / Heating

With pyridine; nitric acid; boron trichloride; iron; potassium carbonate; ammonium chloride; acetic acid; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00577-2

Reference yield:

methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate (61032-41-5) → (4-chloro-3-cyano-6-methoxy-7-quinolyl)trifluoromethanesulfonate (364793-72-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: BCl₃ / CH₂Cl₂

2.1: pyridine / CH₂Cl₂

3.1: Fe; aq. NH₄Cl / methanol

4.2: nBuLi / tetrahydrofuran

5.1: POCl₃ / Heating

With pyridine; boron trichloride; iron; ammonium chloride; trichlorophosphate; In methanol; dichloromethane;

DOI:10.1016/S0960-894X(02)00577-2

upstream raw materials:

3-cyano-6-methoxy-4-oxo-1,4-dihydro-7-quinolinyl trifluoromethanesulfonate

4-hydroxy-3-methoxybenzoic acid methyl ester

methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate

methyl 4-(benzyloxy)-3-methoxybenzoate

Downstream raw materials:

3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxyquinolin-7-yl trifluoromethanesulfonate

3-cyano-6-methoxy-4-[(3,4,5-trimethoxyphenyl)amino]quinolin-7-yl trifluoromethanesulfonate

Refernces

• 1、 -. "3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors". . . Retrieved 2008/06/13.