1-Bromo-2-(methylsulfonyl)benzene

Base Information

• Chemical Name: 1-Bromo-2-(methylsulfonyl)benzene
• CAS No.: 33951-33-6
• Molecular Formula: C7H7BrO2S
• Molecular Weight: 235.101
• Hs Code.: 2904909090
• Mol file: 33951-33-6.mol

Synonyms:Sulfone,o-bromophenyl methyl (6CI,8CI);1-Bromo-2-(methylsulfonyl)benzene;2-Bromophenyl methyl sulfone;o-Bromo(methylsulfonyl)benzene;o-Bromophenylmethyl sulfone;

Chemical Property of 1-Bromo-2-(methylsulfonyl)benzene

Chemical Property:

• Vapor Pressure: 4.26E-05mmHg at 25°C
• Melting Point: 106-110 °C
• Refractive Index: 1.563
• Boiling Point: 361.6 °C at 760 mmHg
• Flash Point: 172.5 °C
• PSA: 42.52000
• Density: 1.595 g/cm³
• LogP: 2.93340
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.0%Min ^*data from raw suppliers

2-Bromophenyl methyl sulfone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 1-Bromo-2-(methylsulfonyl)benzene

There total 12 articles about 1-Bromo-2-(methylsulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo-1-(methylsulfanyl)benzene (19614-16-5) → 1-bromo-2-(methylsulfonyl)benzene (33951-33-6)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; water; lithium perchlorate; acetic acid; at 20 ℃; for 8h; chemoselective reaction; Electrochemical reaction;

DOI:10.1016/j.elecom.2019.106583

Reference yield: 81.0%

3-bromo-1-(methylthio)benzene (33733-73-2) → 1-bromo-2-(methylsulfonyl)benzene (33951-33-6) + (S)-methyl o-bromophenyl sulfoxide (7321-58-6,126218-83-5,146235-11-2)

Guidance literature:

With phosphate buffer; dihydrogen peroxide; chiral Al(salalen); In methanol; at 20 ℃; for 24h;

DOI:10.1002/anie.200700792

Reference yield:

bromobenzene (108-86-1,52753-63-6) + methanesulfonic acid (75-75-2,98527-29-8) → 1-bromo-2-(methylsulfonyl)benzene (33951-33-6) + 4-bromoohenyl methyl sulfone (3466-32-8)

Guidance literature:

With solid phase supported aluminium triflate; at 40 ℃; for 3.3h; chemoselective reaction; Neat (no solvent);

DOI:10.5012/bkcs.2010.31.7.1887

upstream raw materials:

2-bromo-1-(methylsulfanyl)benzene

ortho-bromobenzenesulfinic acid

1-bromo-2-(methylsulfinyl)benzene

3-bromo-1-(methylthio)benzene

Downstream raw materials:

1-[2-(methylsulfonyl)phenyl]piperazine

8-(2'-methanesulfonyl-biphenyl-3-yl)-6-(1-methanesulfonyl-1-methyl-ethyl)-quinoline

4,4,5,5-tetramethyl-2-(2-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane

N-(3-chlorophenethyl)-2,4,6-trimethyl-N-((2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide

Refernces

• 1、 Zhao, Bin,Hammond, Gerald B.,Xu, Bo. "Modulation of photochemical oxidation of thioethers to sulfoxides or sulfones using an aromatic ketone as the photocatalyst". supporting information. . Retrieved 2021/09/13.
• 2、 Lian, Chen,Li, Hai-Lou,Yang, Guo-Yu. "A μ-AsO4-Bridging Hexadecanuclear Ni-Substituted Polyoxotungstate". . p. 3996 - 4003. Retrieved 2021/04/07.