4-AMINOMETHYL-BENZOIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-AMINOMETHYL-BENZOIC ACID ETHYL ESTER
• CAS No.: 366-84-7
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 2922499990
• Mol file: 366-84-7.mol

Synonyms:4-carboethoxybenzylamine;4-Aminomethylbenzoesaeureethylester;ethyl 4-aminomethylbenzoate;4-Aminomethyl-benzoic acid ethyl ester;p-Aminomethylbenzoesaeureethylester;4-ethoxycarbonylbenzylamine;

Chemical Property of 4-AMINOMETHYL-BENZOIC ACID ETHYL ESTER

Chemical Property:

• PSA: 52.32000
• LogP: 2.02230
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%Min ^*data from raw suppliers

Ethyl 4-(aminomethyl)benzoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINOMETHYL-BENZOIC ACID ETHYL ESTER

There total 14 articles about 4-AMINOMETHYL-BENZOIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 4-cyanobenzoate (7153-22-2) → ethyl 4-(aminomethyl)benzoate (366-84-7)

Guidance literature:

ethyl 4-cyanobenzoate; With C₄₈H₆₂ErN₇O₂Si₂; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In toluene; at 110 ℃; for 6h; Inert atmosphere;

With silica gel; In methanol; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.inorgchem.8b02067

Reference yield: 90.0%

p-aminomethylbenzoic acid (56-91-7) + ethanol (64-17-5) → ethyl 4-(aminomethyl)benzoate (366-84-7)

Guidance literature:

With thionyl chloride; at 20 ℃; for 4.5h; Cooling with ice; Reflux;

Reference yield: 87.0%

→ ethyl 4-(aminomethyl)benzoate (366-84-7)

Guidance literature:

upstream raw materials:

p-aminomethylbenzoic acid

ethanol

ethyl 4-cyanobenzoate

hexamethylenetetramine

Downstream raw materials:

4-Aminomethyl-benzoesaeurehydrazid

N-(4-ethoxycarbonylbenzyl)-4-ethoxycarbonylbenzaldimine

C₁₈H₂₀N₂O₃

C₁₄H₁₅N₃O₃

Refernces

• 1、 Liu, Wen-Shan,Wang, Rui-Rui,Yue, Hai,Zheng, Zhi-Hui,Lu, Xin-Hua,Wang, Shu-Qing,Dong, Wei-Li,Wang, Run-Ling. "Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors". . p. 3814 - 3824. Retrieved 2019/11/03.
• 2、 Bukhari, Shazreh,Cabral, Aaron D.,Gawel, Justyna M.,Gunning, Patrick T.,Israelian, Johan,Manaswiyoungkul, Pimyupa,Nawar, Nabanita,Olaoye, Olasunkanmi O.,Radu, Tudor B.,Raouf, Yasir S.,Sedighi, Abootaleb,Shouksmith, Andrew E.,Sina, Diana,Toutah, Krimo,de Araujo, Elvin D.. "PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia". . . Retrieved 2020/07/03.