2-chloromethylbenzofuran

Base Information

• Chemical Name: 2-chloromethylbenzofuran
• CAS No.: 36754-60-6
• Molecular Formula: C9H7ClO
• Molecular Weight: 166.607
• Hs Code.: 2932999099
• Mol file: 36754-60-6.mol

Synonyms:2-Chloromethyl-1-benzofuran;chloromethyl-arsane;2-chloromethyl-benzofuran;chloromethylbenzofuran;2-Chlormethyl-benzofuran;

Chemical Property of 2-chloromethylbenzofuran

Chemical Property:

• Vapor Pressure: 0.0336mmHg at 25°C
• PSA: 13.14000
• LogP: 3.17160

Purity/Quality:

97% ^*data from raw suppliers

2-(chloromethyl)-1-benzofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloromethylbenzofuran

There total 9 articles about 2-chloromethylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

benzofuran-2-yl-methanol (55038-01-2) → 2-(chloromethyl)-1-benzofuran (36754-60-6)

Guidance literature:

With thionyl chloride; In toluene; at 0 ℃; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1021/acs.orglett.6b00559

Reference yield: 22.0%

1-benzofurane (271-89-6) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 2-(chloromethyl)-1-benzofuran (36754-60-6)

Guidance literature:

With hydrogenchloride; In benzene; for 1.5h; Ambient temperature;

DOI:10.1021/jm00085a002

Reference yield:

1-benzofurane (271-89-6) → 2-(chloromethyl)-1-benzofuran (36754-60-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / POCl₃ / 20 h / 100 °C

2: NaBH₄ / methanol / 20 °C

3: SOCl₂; benzotriazole / CH₂Cl₂

With 1,2,3-Benzotriazole; sodium tetrahydroborate; thionyl chloride; trichlorophosphate; In methanol; dichloromethane;

DOI:10.1002/chem.200501034

upstream raw materials:

benzofuran-2-yl-methanol

1-benzofurane

formaldehyd

2-formylbenzo[b]furan

Downstream raw materials:

3-allyl benzofuran

o-allenylphenyl acetate

1-methoxy-2-(propa-1,2-dien-1-yl)benzene

1-(2-methylbenzofuran-3-yl)ethan-1-one

Refernces

• 1、 Tian, Qingshan,Bai, Jing,Chen, Bin,Zhang, Guozhu. "Chromium-Catalyzed Asymmetric Dearomatization Addition Reactions of Halomethyl Heteroarenes". supporting information. p. 1828 - 1831. Retrieved 2016/05/19.
• 2、 Banerjee, Tuhin Suvro,Paul, Sibasish,Sinha, Surajit,Das, Sumantra. "Synthesis of iboga-like isoquinuclidines: Dual opioid receptors agonists having antinociceptive properties". . p. 6062 - 6070. Retrieved 2015/02/02.