5(4H)-Isoxazolone, 4-cyclopentylidene-3-phenyl-

Base Information

• Chemical Name: 5(4H)-Isoxazolone, 4-cyclopentylidene-3-phenyl-
• CAS No.: 36771-30-9
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.263
• DSSTox Substance ID: DTXSID10474132
• Wikidata: Q82303941
• Mol file: 36771-30-9.mol

Synonyms:36771-30-9;4-Cyclopentylidene-3-phenylisoxazol-5(4H)-one;5(4H)-Isoxazolone, 4-cyclopentylidene-3-phenyl-;DTXSID10474132

Chemical Property of 5(4H)-Isoxazolone, 4-cyclopentylidene-3-phenyl-

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 227.094628657
• Heavy Atom Count: 17
• Complexity: 381

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(=C2C(=NOC2=O)C3=CC=CC=C3)C1

Technology Process of 5(4H)-Isoxazolone, 4-cyclopentylidene-3-phenyl-

There total 5 articles about 5(4H)-Isoxazolone, 4-cyclopentylidene-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

3-phenyl-4H-isoxazol-5-one (1076-59-1) + cyclopentanone (120-92-3) → 4-cyclopentylidene-3-phenylisoxazol-5(4H)-one (36771-30-9)

Guidance literature:

With piperidine; In isopropyl alcohol; at 50 ℃;

DOI:10.1021/acs.orglett.5b01004

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) → 4-cyclopentylidene-3-phenylisoxazol-5(4H)-one (36771-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol / Reflux

1.2: Reflux

2.1: piperidine / isopropyl alcohol / 50 °C

With piperidine; hydroxylamine hydrochloride; sodium acetate; In ethanol; isopropyl alcohol;

DOI:10.1021/acs.orglett.5b01004

Reference yield:

4-cyclopent-1-enyl-3-phenyl-2H-isoxazol-5-one; compound with morpholine (1:1) (36771-31-0) → 4-cyclopentylidene-3-phenylisoxazol-5(4H)-one (36771-30-9)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane;

DOI:10.1039/P19720001240

upstream raw materials:

3-phenyl-4H-isoxazol-5-one

cyclopentanone

4-cyclopent-1-enyl-3-phenyl-2H-isoxazol-5-one; compound with morpholine (1:1)

1-(N-morpholino)cyclopent-1-ene

Downstream raw materials:

4,5-dihydro-2-phenylcyclopentapyrrole

4-Cyclopentyl-3-phenyl-4H-isoxazol-5-one

4,5-dihydro-2-phenylcyclopentapyrrole-3-carboxylic acid

1-(5-Oxo-3-phenyl-4,5-dihydro-isoxazol-4-yl)-cyclopentanecarbonitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 36771-30-9 5(4H)-Isoxazolone, 4-cyclopentylidene-3-phenyl-

Send

Send

Metric Ton KG G Pound L ML

Send

Send