4-Methoxybenzene-1-sulfonyl fluoride

Base Information

• Chemical Name: 4-Methoxybenzene-1-sulfonyl fluoride
• CAS No.: 368-91-2
• Molecular Formula: C7H7FO3S
• Molecular Weight: 190.195
• European Community (EC) Number: 809-012-8
• DSSTox Substance ID: DTXSID20496941
• Nikkaji Number: J1.198.822I
• Wikidata: Q82346146
• Mol file: 368-91-2.mol

Synonyms:368-91-2;4-Methoxybenzene-1-sulfonyl fluoride;4-methoxybenzenesulfonyl fluoride;4-Methoxy-benzenesulfonyl fluoride;Benzenesulfonyl fluoride, 4-methoxy-;4-methoxybenzenesulfonylfluoride;4-methoxyphenylsulfonyl fluoride;SCHEMBL3599210;4-Methoxy-benzenesulfonylfluoride;DTXSID20496941;QHEMDSDRFAIOOU-UHFFFAOYSA-N;AKOS022536840;VS-0063;4-Methoxybenzenesulfonyl fluoride, 95%;CS-0159344;EN300-224382

Chemical Property of 4-Methoxybenzene-1-sulfonyl fluoride

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 190.00999342
• Heavy Atom Count: 12
• Complexity: 224

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)S(=O)(=O)F

Technology Process of 4-Methoxybenzene-1-sulfonyl fluoride

There total 20 articles about 4-Methoxybenzene-1-sulfonyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-methoxy-phenyl-sulphonyl chloride (98-68-0) → 4-methoxybenzene-1-sulfonyl fluoride (368-91-2)

Guidance literature:

With potassium hydrogen difluoride; In water; acetonitrile; at 20 ℃; for 21h;

DOI:10.1055/s-0037-1610877

Reference yield: 95.0%

4-methoxybenzene sulfonamide (1129-26-6) → 4-methoxybenzene-1-sulfonyl fluoride (368-91-2)

Guidance literature:

With potassium fluoride; pyrylium tetrafluoroborate; magnesium chloride; In acetonitrile; at 60 ℃; for 2h;

DOI:10.1002/ejoc.202000022

Reference yield: 85.0%

(E)-1-(4-methoxyphenyl)-2-(methylsulfonyl)diazene → 4-methoxybenzene-1-sulfonyl fluoride (368-91-2)

Guidance literature:

With potassium pyrosulfite; N-fluorobis(benzenesulfon)imide; In water; acetonitrile; at 20 ℃; for 4h; Reagent/catalyst; Solvent; Wavelength; Mechanism; Irradiation; Green chemistry;

DOI:10.1002/adsc.202100951

upstream raw materials:

4-methoxy-phenyl-sulphonyl chloride

1-methoxy-4-phenoxy-benzene

fluorosulphonic acid

methoxybenzene

Downstream raw materials:

4-methoxybenzene sulfonamide

4-methoxy-3-nitro-benzenesulfonyl fluoride

Dimethyloxosulfonium-<4-methoxy-phenyl>-sulfonyl-methylid

2,2,2-trifluoro-N-{1-[4-(4-methoxy-benzenesulfonyl)-phenyl]-ethyl}-acetamide