1-(4-Methylphenyl)-2,2,2-trifluoroethyltosylate

Base Information

Chemical Name:1-(4-Methylphenyl)-2,2,2-trifluoroethyltosylate
CAS No.:84877-44-1
Molecular Formula:C16H15F3O3S
Molecular Weight:344.355
Hs Code.:
NSC Number:142254
Nikkaji Number:J302.790B

Synonyms:84877-44-1;NSC142254;NSC-142254;1-p-tolyl-2,2,2-trifluoroethyl tosylate

Suppliers and Price of 1-(4-Methylphenyl)-2,2,2-trifluoroethyltosylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 1-(4-Methylphenyl)-2,2,2-trifluoroethyltosylate

Chemical Property:

Vapor Pressure:4.07E-07mmHg at 25°C
Boiling Point:427.5°C at 760 mmHg
Flash Point:212.3°C
Density:1.302g/cm³
XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:344.06940000
Heavy Atom Count:23
Complexity:468

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(C(F)(F)F)OS(=O)(=O)C2=CC=C(C=C2)C

Technology Process of 1-(4-Methylphenyl)-2,2,2-trifluoroethyltosylate

There total 4 articles about 1-(4-Methylphenyl)-2,2,2-trifluoroethyltosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 446-65-1
2,2,2-trifluoro-1-(4-methylphenyl)ethanol

: 98-59-9
p-toluenesulfonyl chloride

: 84877-44-1
toluene-4-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jo302065u

Reference yield:

: (±)-trimethyl(2,2,2-trifluoro-1-(4-methylphenyl)ethoxy)silane

: 84877-44-1
toluene-4-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 4 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo302065u

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 84877-44-1
toluene-4-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

3: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 4 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo302065u