3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one

Base Information

Chemical Name:3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one
CAS No.:5812-07-7
Molecular Formula:C17H16N2O
Molecular Weight:264.3217
Hs Code.:
European Community (EC) Number:637-321-6
NSC Number:86429
Nikkaji Number:J1.049.108H,J2.841.841H
Pharos Ligand ID:S7YA56XDPC2R
ChEMBL ID:CHEMBL328710
Mol file:5812-07-7.mol

Synonyms:3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one;SU 4312;SU-4312;SU4312

Suppliers and Price of 3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SU 4312
10mg
$ 545.00

TRC
SU4312
10mg
$ 265.00

Tocris
SU4312
10
$ 182.00

DC Chemicals
SU4312(NSC86429) >98%
1 g
$ 1200.00

CSNpharm
SU4312
50mg
$ 512.00

CSNpharm
SU4312
100mg
$ 791.00

CSNpharm
SU4312
5mg
$ 93.00

CSNpharm
SU4312
10mg
$ 158.00

ChemScene
SU4312 98.19%
10mg
$ 170.00

ChemScene
SU4312 98.19%
100mg
$ 850.00

Total 12 raw suppliers

Chemical Property of 3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one

Chemical Property:

Vapor Pressure:5.09E-10mmHg at 25°C
Melting Point:225-232 °C
Boiling Point:497.1°C at 760 mmHg
PKA:12.89±0.20(Predicted)
Flash Point:254.5°C
PSA：32.34000
Density:1.219g/cm³
LogP:3.38330
Storage Temp.:2-8°C
Solubility.:DMSO: 30 mg/mL
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:264.126263138
Heavy Atom Count:20
Complexity:394

Purity/Quality:

99%, ^*data from raw suppliers

SU 4312 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CN(C)C1=CC=C(C=C1)C=C2C3=CC=CC=C3NC2=O
Isomeric SMILES:CN(C)C1=CC=C(C=C1)/C=C\2/C3=CC=CC=C3NC2=O
Description SU-4312 (5812-07-7) is a potent selective inhibitor of VEGFR kinase (also known as Flk-1 and KDR). Inhibition of the activated kinase (IC50 = 0.4 μM) is 100-fold less than inhibition of the unactivated kinase (IC50 = 0.04 μM). SU-4312 also inhibits PDGFR kinase (IC50 = 19.4 μM).
Uses SU 4312 is a vascular endothelial growth factor receptor KDR tyrosine kinase antagonist.

Technology Process of 3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one

There total 8 articles about 3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%