6-chloro-5-Methylpyridine-3-sulfonyl chloride

Base Information

• Chemical Name: 6-chloro-5-Methylpyridine-3-sulfonyl chloride
• CAS No.: 37105-10-5
• Molecular Formula: C6H5Cl2NO2S
• Molecular Weight: 226.083
• Hs Code.: 2933399990
• Mol file: 37105-10-5.mol

Synonyms:6-Chlor-5-methyl-3-pyridinsulfonylchlorid;6-Chloro-5-methyl-pyridine-3-sulfonyl chloride;6-chloro-5-methylpyridine-3-sulfonyl chloride;

Chemical Property of 6-chloro-5-Methylpyridine-3-sulfonyl chloride

Chemical Property:

• Melting Point: 56 - 57 °C
• Boiling Point: 330.2±42.0 °C(Predicted)
• PKA: -4.68±0.10(Predicted)
• PSA: 55.41000
• Density: 1.532±0.06 g/cm3(Predicted)
• LogP: 3.05170

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-5-methyl-pyridine-3-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-5-Methylpyridine-3-sulfonyl chloride

There total 3 articles about 6-chloro-5-Methylpyridine-3-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.3%

6-chloro-5-methylpyridin-3-amine (38186-82-2) → 6-chloro-5-methyl-3-pyridinesulfonyl chloride (37105-10-5)

Guidance literature:

6-chloro-5-methylpyridin-3-amine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.7h;

With hydrogenchloride; copper(ll) sulfate pentahydrate; sodium hydrogensulfite; In water; at 0 - 5 ℃;

Reference yield:

2-chloro-3-methyl-5-nitropyridine (22280-56-4) → 6-chloro-5-methyl-3-pyridinesulfonyl chloride (37105-10-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iron; ammonium chloride / methanol / 2.83 h / 40 °C / Heating

2.1: hydrogenchloride; sodium nitrite / water / 5 °C

2.2: 0.5 h / Cooling with ice

With hydrogenchloride; iron; ammonium chloride; sodium nitrite; In methanol; water;

Reference yield:

→ 6-chloro-5-methyl-3-pyridinesulfonyl chloride (37105-10-5)

Guidance literature:

6-Hydroxy-5-methyl-3-pyridinsulfonsaeure-Na-salz, Phosphoroxychlorid;

upstream raw materials:

6-chloro-5-methylpyridin-3-amine

2-chloro-3-methyl-5-nitropyridine

Downstream raw materials:

1-[(6-chloro-5-methylpyridin-3-yl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde

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