(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone

Base Information

Chemical Name:(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone
CAS No.:180083-23-2
Molecular Formula:C32H32 N4 O3
Molecular Weight:520.631
Hs Code.:
UNII:F95C648W4N
DSSTox Substance ID:DTXSID4043987
Nikkaji Number:J854.001B
Wikidata:Q27088711
Pharos Ligand ID:R94DQQRK7BC4
Metabolomics Workbench ID:63120
ChEMBL ID:CHEMBL281350
Mol file:180083-23-2.mol

(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone

Synonyms:1'-methyl-5-(2'-methyl-4'-((5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)carbonyl)-2,3,6,7-tetrahydrospiro(furo(2,3-f)indole-3,4'-piperidone) hemioxalate;SB 224289;SB 22489G;SB-224289;SB-22489G;SB224289

Suppliers and Price of (2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SB224289
2.5mg
$ 775.00

Tocris
SB224289hydrochloride ≥95%(HPLC)
10
$ 212.00

Tocris
SB224289hydrochloride ≥95%(HPLC)
50
$ 899.00

Matrix Scientific
(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone 95+%
1g
$ 4725.00

Crysdot
(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone 95+%
1g
$ 1980.00

Chemenu
(2''-Methyl-4''-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1''-biphenyl]-4-yl)(1''-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4''-piperidin]-5(2H)-yl)methanone 95%
1g
$ 1866.00

Alichem
(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone
1g
$ 1680.00

AK Scientific
(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone
1g
$ 6428.00

Total 22 raw suppliers

Chemical Property of (2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone

Chemical Property:

Melting Point:>280℃
Boiling Point:724.8±70.0 °C(Predicted)
PKA:9.85±0.20(Predicted)
PSA：71.70000
Density:1.34
LogP:6.38400
Storage Temp.:Store at RT
Solubility.:DMSO: 4.5 mg/mL
XLogP3:5.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:520.24744090
Heavy Atom Count:39
Complexity:885

Purity/Quality:

99%, ^*data from raw suppliers

SB224289 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=CC6=C(C=C54)C7(CCN(CC7)C)CO6
Uses SB 224289A is a 5-HT1B antagonist and a useful compound to examine the role of 5-HT1B receptors in cocaine self-administration and cocaine-seeking behavior (1,2).

Technology Process of (2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone

There total 10 articles about (2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%