1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-2-[(phenylmethoxy)methyl]-5-[tris(1-methylethyl)silyl]-, (1R,2S)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)-

Base Information

Chemical Name:1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-2-[(phenylmethoxy)methyl]-5-[tris(1-methylethyl)silyl]-, (1R,2S)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)-
CAS No.:372109-60-9
Molecular Formula:C38H55NO4Si
Molecular Weight:617.945
Hs Code.:
Mol file:372109-60-9.mol

1(2H)-Pyridinecarboxylic acid,
3,4-dihydro-4-oxo-2-[(phenylmethoxy)methyl]-5-[tris(1-methylethyl)silyl]-,
(1R,2S)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)-

Synonyms:

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Chemical Property of 1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-2-[(phenylmethoxy)methyl]-5-[tris(1-methylethyl)silyl]-, (1R,2S)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)-

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Technology Process of 1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-2-[(phenylmethoxy)methyl]-5-[tris(1-methylethyl)silyl]-, (1R,2S)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)-

There total 5 articles about 1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-2-[(phenylmethoxy)methyl]-5-[tris(1-methylethyl)silyl]-, (1R,2S)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126378-42-5
4-methoxy-3-(trisopropylsilyl)pyridine

: 372109-60-9
(2S)-1-[(1R,2S)-trans-2-(α-cumyl)cyclohexyloxycarbonyl]-2-(benzyloxymethyl)-5-(triisopropylsilyl)-2,3-dihydro-4-pyridone

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 1 h / -30 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: lithium (2-thienyl)cyanocuprate / tetrahydrofuran; hexane; diethyl ether / 0.5 h / -78 °C

2.3: tetrahydrofuran; diethyl ether; toluene / 1 h / -78 °C

3.1: 215 mg / aqueous hydrochloric acid / tetrahydrofuran; diethyl ether; toluene / 1 h

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; toluene;
DOI:10.1021/jo015834u

Reference yield:

: (1R,2S)-2-(1-methyl-1-phenylethyl)cyclohexyl chloroformate

: 372109-60-9
(2S)-1-[(1R,2S)-trans-2-(α-cumyl)cyclohexyloxycarbonyl]-2-(benzyloxymethyl)-5-(triisopropylsilyl)-2,3-dihydro-4-pyridone

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 1 h / -30 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: lithium (2-thienyl)cyanocuprate / tetrahydrofuran; hexane; diethyl ether / 0.5 h / -78 °C

2.3: tetrahydrofuran; diethyl ether; toluene / 1 h / -78 °C

3.1: 215 mg / aqueous hydrochloric acid / tetrahydrofuran; diethyl ether; toluene / 1 h

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; toluene;
DOI:10.1021/jo015834u

Reference yield:

: 4-Methoxy-1-[(1R,2S)-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride

: 372109-60-9
(2S)-1-[(1R,2S)-trans-2-(α-cumyl)cyclohexyloxycarbonyl]-2-(benzyloxymethyl)-5-(triisopropylsilyl)-2,3-dihydro-4-pyridone

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: lithium (2-thienyl)cyanocuprate / tetrahydrofuran; hexane; diethyl ether / 0.5 h / -78 °C

1.3: tetrahydrofuran; diethyl ether; toluene / 1 h / -78 °C

2.1: 215 mg / aqueous hydrochloric acid / tetrahydrofuran; diethyl ether; toluene / 1 h

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; toluene;
DOI:10.1021/jo015834u