6-Bromo-1-(3,4-dihydro-2H-pyrrol-5-yl)-9H-pyrido[3,4-b]indol-7-ol

Base Information

Chemical Name:6-Bromo-1-(3,4-dihydro-2H-pyrrol-5-yl)-9H-pyrido[3,4-b]indol-7-ol
CAS No.:88704-49-8
Molecular Formula:C₁₅H₁₃N₃O
Molecular Weight:251.288
Hs Code.:2933990090
Mol file:88704-49-8.mol

Synonyms:

Suppliers and Price of 6-Bromo-1-(3,4-dihydro-2H-pyrrol-5-yl)-9H-pyrido[3,4-b]indol-7-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-Bromo-1-(3,4-dihydro-2H-pyrrol-5-yl)-9H-pyrido[3,4-b]indol-7-ol

Chemical Property:

Vapor Pressure:8.88E-11mmHg at 25°C
Boiling Point:516.6°C at 760 mmHg
Flash Point:266.2°C
PSA：57.78000
Density:1.79g/cm³
LogP:1.48230

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-Bromo-1-(3,4-dihydro-2H-pyrrol-5-yl)-9H-pyrido[3,4-b]indol-7-ol

There total 9 articles about 6-Bromo-1-(3,4-dihydro-2H-pyrrol-5-yl)-9H-pyrido[3,4-b]indol-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 108061-67-2
6-methoxy-1-(1-pyrrolin-2-yl)-β-carboline

: 88704-49-8
eudistomin Q

Guidance literature:: With boron tribromide; In dichloromethane; 1,2-dichloro-ethane; for 0.166667h; Heating;
DOI:10.1021/ja00245a031

Reference yield:

: 17952-63-5
6-methoxy-2,3,4,9-tetrahydro-1H-β-carboline-1-carboxylic acid

: 88704-49-8
eudistomin Q

Guidance literature:: Multi-step reaction with 9 steps

1: 97 percent / HCl / Ambient temperature

2: 77 percent / conc. aq. NH₄OH / Ambient temperature

3: 70 percent / 5percent Pd/C / xylene / 2 h / Heating

4: 65 percent / POCl₃, pyridine / dimethylformamide / 1 h / 0 °C

5: 2.) sodium borohydride / 1.) THF, r.t., 1 h, 2.) THF, MeOH, 0.5 h

6: 68 percent / 17.5percent aq. HClO₄ / tetrahydrofuran / 3 h / Ambient temperature

7: 77 percent / borane-trimethylamine / tetrahydrofuran; acetic acid / 1 h / 0 °C

8: 1.) 5.25percent NaOCl, 2.) Na₂CO₃ / 1.) MeOH, 10 min, 2.) MeOH, 1 h

9: 23 percent / boron tribromide / CH₂Cl₂; 1,2-dichloro-ethane / 0.17 h / Heating

With pyridine; hydrogenchloride; ammonium hydroxide; sodium hypochlorite; sodium tetrahydroborate; perchloric acid; trimethylamine-borane; boron tribromide; sodium carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; xylene;
DOI:10.1021/ja00245a031

Reference yield:

: 108061-51-4
1-carbamoyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline

: 88704-49-8
eudistomin Q

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / 5percent Pd/C / xylene / 2 h / Heating

2: 65 percent / POCl₃, pyridine / dimethylformamide / 1 h / 0 °C

3: 2.) sodium borohydride / 1.) THF, r.t., 1 h, 2.) THF, MeOH, 0.5 h

4: 68 percent / 17.5percent aq. HClO₄ / tetrahydrofuran / 3 h / Ambient temperature

5: 77 percent / borane-trimethylamine / tetrahydrofuran; acetic acid / 1 h / 0 °C

6: 1.) 5.25percent NaOCl, 2.) Na₂CO₃ / 1.) MeOH, 10 min, 2.) MeOH, 1 h

7: 23 percent / boron tribromide / CH₂Cl₂; 1,2-dichloro-ethane / 0.17 h / Heating

With pyridine; sodium hypochlorite; sodium tetrahydroborate; perchloric acid; trimethylamine-borane; boron tribromide; sodium carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; xylene;
DOI:10.1021/ja00245a031