4H-1,4-Benzoxazine-4-pentanoic acid, 2,3-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-, phenylmethyl ester

Base Information

Chemical Name:4H-1,4-Benzoxazine-4-pentanoic acid, 2,3-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-, phenylmethyl ester
CAS No.:374108-79-9
Molecular Formula:C31H33NO7
Molecular Weight:531.606
Hs Code.:
Mol file:374108-79-9.mol

Synonyms:

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Chemical Property of 4H-1,4-Benzoxazine-4-pentanoic acid, 2,3-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-, phenylmethyl ester

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Technology Process of 4H-1,4-Benzoxazine-4-pentanoic acid, 2,3-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-, phenylmethyl ester

There total 8 articles about 4H-1,4-Benzoxazine-4-pentanoic acid, 2,3-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 374108-79-9
5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 62 percent / potassium carbonate / dimethylformamide / 17 h / 20 °C

2.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2327.17 Torr

3.1: 46.8 g / imidazole / dimethylformamide / 15 h / 0 - 20 °C

4.1: sodium hydride / dimethylformamide / 0 °C

4.2: dimethylformamide / 0 - 20 °C

4.3: aq. CH₃SO₃H / methanol / 20 °C

5.1: tributylphosphine; 1,1'-(azodicarbonyl)dipiperidine / benzene / 20 °C

With 1H-imidazole; tributylphosphine; hydrogen; sodium hydride; potassium carbonate; 1,1'-azodicarbonyl-dipiperidine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; benzene; 5.1: Mitsunobu reaction;
DOI:10.1021/jm0301888

Reference yield:

: 58835-34-0
3-(2-nitrophenoxy)dihydrofuran-2-one

: 374108-79-9
5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2327.17 Torr

2.1: 46.8 g / imidazole / dimethylformamide / 15 h / 0 - 20 °C

3.1: sodium hydride / dimethylformamide / 0 °C

3.2: dimethylformamide / 0 - 20 °C

3.3: aq. CH₃SO₃H / methanol / 20 °C

4.1: tributylphosphine; 1,1'-(azodicarbonyl)dipiperidine / benzene / 20 °C

With 1H-imidazole; tributylphosphine; hydrogen; sodium hydride; 1,1'-azodicarbonyl-dipiperidine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; benzene; 4.1: Mitsunobu reaction;
DOI:10.1021/jm0301888