5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid

Base Information

Chemical Name:5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid
CAS No.:374108-80-2
Molecular Formula:C₂₄H₂₇NO₇
Molecular Weight:441.481
Hs Code.:

Synonyms:5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid

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Chemical Property of 5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid

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Technology Process of 5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid

There total 8 articles about 5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374108-79-9
5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid benzyl ester

: 374108-80-2
5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 3h; under 2585.74 Torr;
DOI:10.1021/jm0301888

Reference yield:

: 2067-33-6
5-bromopentanoic acid

: 374108-80-2
5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; N,N-(dimethylamino)pyridine / CH₂Cl₂ / 7 h / 20 °C

2.1: sodium hydride / dimethylformamide / 0 °C

2.2: dimethylformamide / 0 - 20 °C

2.3: aq. CH₃SO₃H / methanol / 20 °C

3.1: tributylphosphine; 1,1'-(azodicarbonyl)dipiperidine / benzene / 20 °C

4.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2585.74 Torr

With dmap; tributylphosphine; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1'-azodicarbonyl-dipiperidine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 3.1: Mitsunobu reaction;
DOI:10.1021/jm0301888

Reference yield:

: 60343-28-4
Benzyl 5-bromovalerate

: 374108-80-2
5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethylformamide / 0 °C

1.2: dimethylformamide / 0 - 20 °C

1.3: aq. CH₃SO₃H / methanol / 20 °C

2.1: tributylphosphine; 1,1'-(azodicarbonyl)dipiperidine / benzene / 20 °C

3.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2585.74 Torr

With tributylphosphine; hydrogen; sodium hydride; 1,1'-azodicarbonyl-dipiperidine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; benzene; 2.1: Mitsunobu reaction;
DOI:10.1021/jm0301888