1-Oxa-8-azaspiro[4.5]decane, 2,2-dimethyl-

Base Information

• Chemical Name: 1-Oxa-8-azaspiro[4.5]decane, 2,2-dimethyl-
• CAS No.: 374794-94-2
• Molecular Formula: C₁₀H₁₉NO
• Molecular Weight: 169.267
• Hs Code.: 2934999090
• Mol file: 374794-94-2.mol

Synonyms:2,2-Dimethyl-1-oxa-4-azaspiro<4.5>dec-3-en-N-oxid;

Chemical Property of 1-Oxa-8-azaspiro[4.5]decane, 2,2-dimethyl-

Chemical Property:

• Vapor Pressure: 0.033mmHg at 25°C
• Boiling Point: 242.816oC at 760 mmHg
• Flash Point: 96.496oC
• PSA: 21.26000
• Density: 0.988g/cm3
• LogP: 2.02640
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2,2-Dimethyl-1-oxa-8-azaspiro[4.5]decane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Oxa-8-azaspiro[4.5]decane, 2,2-dimethyl-

There total 2 articles about 1-Oxa-8-azaspiro[4.5]decane, 2,2-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1,1-dimethylethyl 4-hydroxy-4-(3-hydroxy-3-methylbut-1-yl)-1-piperidinecarboxylate (374794-93-1) → 2,2-dimethyl-1-oxa-8-azaspiro[4.5]decane (374794-94-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield: 89.0%

1,1-dimethylethyl 4-hydroxy-4-(3-hydroxy-3-methylbut-1-yl)-1-piperidinecarboxylate → 2,2-dimethyl-1-oxa-8-azaspiro[4.5]decane (374794-94-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

2,2-dimethyl-1-oxa-8-azaspiro[4.5]decane (374794-94-2) + (RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide (374791-10-3) → 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2,2-dimethyl-1-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide + 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2,2-dimethyl-1-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide

Guidance literature:

With sodium cyanoborohydride; zinc(II) chloride; In methanol; at 20 ℃; for 16h;

DOI:10.1016/S0960-894X(02)00250-0

upstream raw materials:

1,1-dimethylethyl 4-hydroxy-4-(3-hydroxy-3-methylbut-1-yl)-1-piperidinecarboxylate

Refernces

• 1、 -. "Cyclohexane derivatives and their use as therapeutic agents". Page 29. . Retrieved 2010/02/06.