(RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

Base Information

• Chemical Name: (RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide
• CAS No.: 374791-10-3
• Molecular Formula: C₂₃H₂₁F₆NO₂
• Molecular Weight: 457.416
• Mol file: 374791-10-3.mol

Synonyms:(RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

Chemical Property of (RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

There total 2 articles about (RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-4-phenylcyclohexan-1-one (95261-39-5) + (RS)-α-Methyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-73-3) → (RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide (374791-10-3)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0960-894X(02)00249-4

Reference yield:

4-oxo-1-phenylcyclohexanecarboxylic acid (75945-91-4) → (RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide (374791-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (PhO)2PON₃; Et₃N / toluene / 90 °C

1.2: aq. HCl / Heating

2.1: EDC; HOBT; Et₃N / dimethylformamide / 20 °C

With diphenyl phosphoryl azide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; toluene; 1.1: Curtius rearrangement;

DOI:10.1016/S0960-894X(02)00249-4

Reference yield: 91.0%

Methyltriphenylphosphonium bromide (1779-49-3) + (RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide (374791-10-3) → (RS)-α-methyl-N-4-(4-methylene-1-phenylcyclohexyl)-3,5-bis(trifluoromethyl) benzeneacetamide (374793-76-7)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

(RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Heating / reflux;

upstream raw materials:

4-amino-4-phenylcyclohexan-1-one

(RS)-α-Methyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

4-oxo-1-phenylcyclohexanecarboxylic acid