1,1-DIMETHYL-2-OXA-8-AZASPIRO[4.5]DECANE HYDROCHLORIDE

Base Information

• Chemical Name: 1,1-DIMETHYL-2-OXA-8-AZASPIRO[4.5]DECANE HYDROCHLORIDE
• CAS No.: 374794-98-6
• Molecular Formula: C₁₀H₁₉NO
• Molecular Weight: 169.267
• Hs Code.: 2934999090
• Mol file: 374794-98-6.mol

Synonyms:1,1-dimethyl-2-oxa-8-azaspiro[4.5]decane;1,1-dimethyl-2-oxa-8-azaspiro[4.5]decane hydrochloride;RW2928,hydrochloride;

Chemical Property of 1,1-DIMETHYL-2-OXA-8-AZASPIRO[4.5]DECANE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 242.8±33.0 °C(Predicted)
• PKA: 10.92±0.40(Predicted)
• PSA: 21.26000
• Density: 0.98±0.1 g/cm3(Predicted)
• LogP: 2.68590
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

1,1-Dimethyl-2-oxa-8-aza-spiro[4.5]decane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-DIMETHYL-2-OXA-8-AZASPIRO[4.5]DECANE HYDROCHLORIDE

There total 2 articles about 1,1-DIMETHYL-2-OXA-8-AZASPIRO[4.5]DECANE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-hydroxy-ethyl)-4-(1-hydroxy-1-methyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (374794-97-5) → 1,1-dimethyl-2-oxa-8-azaspiro[4,5]decane (374794-98-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/S0960-894X(02)00250-0

Reference yield:

→ 1,1-dimethyl-2-oxa-8-azaspiro[4,5]decane (374794-98-6)

Guidance literature:

Reference yield:

1,1-dimethyl-2-oxa-8-azaspiro[4,5]decane (374794-98-6) + (RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide (374791-10-3) → 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(1,1-dimethyl-2-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide + 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(1,1-dimethyl-2-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide

Guidance literature:

With sodium cyanoborohydride; zinc(II) chloride; In methanol; at 20 ℃; for 16h;

DOI:10.1016/S0960-894X(02)00250-0

upstream raw materials:

4-(2-hydroxy-ethyl)-4-(1-hydroxy-1-methyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester