Technology Process of 1H-Isoindole-1,3(2H)-dione,
2-[2-[4-(6-hydroxyhexyl)-2,5-dimethoxyphenyl]-1-methylethyl]-
There total 9 articles about 1H-Isoindole-1,3(2H)-dione,
2-[2-[4-(6-hydroxyhexyl)-2,5-dimethoxyphenyl]-1-methylethyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
at 20 ℃;
for 18h;
DOI:10.3390/71100777
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 94 percent / conc. H2SO4 / 18 h / Heating
2.1: 33 percent / zinc amalgam; conc. HCl / methanol / 3 h / Heating
3.1: phosphorus oxychloride / 2 h / Heating
3.2: 35 percent / H2O / 18 h / 20 °C
4.1: 35 percent / ammonium acetate / acetic acid / 4 h / Heating
5.1: 66 percent / lithium aluminum hydride / diethyl ether / 48 h / Heating
6.1: 95 percent / sodium bicarbonate / tetrahydrofuran; H2O / 18 h / 20 °C
With
ammonium acetate; hydrogenchloride; amalgamated zinc; lithium aluminium tetrahydride; sulfuric acid; sodium hydrogencarbonate; trichlorophosphate;
In
tetrahydrofuran; methanol; diethyl ether; water; acetic acid;
3.1: Vilsmeier-Haack formylation;
DOI:10.3390/71100777
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: aluminum chloride / nitrobenzene / 23 h / 0 - 20 °C
2.1: 11.4 g / 3 M NaOH
3.1: 94 percent / conc. H2SO4 / 18 h / Heating
4.1: 33 percent / zinc amalgam; conc. HCl / methanol / 3 h / Heating
5.1: phosphorus oxychloride / 2 h / Heating
5.2: 35 percent / H2O / 18 h / 20 °C
6.1: 35 percent / ammonium acetate / acetic acid / 4 h / Heating
7.1: 66 percent / lithium aluminum hydride / diethyl ether / 48 h / Heating
8.1: 95 percent / sodium bicarbonate / tetrahydrofuran; H2O / 18 h / 20 °C
With
ammonium acetate; hydrogenchloride; sodium hydroxide; amalgamated zinc; lithium aluminium tetrahydride; aluminium trichloride; sulfuric acid; sodium hydrogencarbonate; trichlorophosphate;
In
tetrahydrofuran; methanol; diethyl ether; water; acetic acid; nitrobenzene;
1.1: Friedel-Crafts acylation / 5.1: Vilsmeier-Haack formylation;
DOI:10.3390/71100777
