3-Morpholin-4-yl-3-oxo-propionic acid ethyl ester

Base Information

• Chemical Name: 3-Morpholin-4-yl-3-oxo-propionic acid ethyl ester
• CAS No.: 37714-64-0
• Molecular Formula: C9H15NO4
• Molecular Weight: 201.222
• Hs Code.: 2934999090
• Mol file: 37714-64-0.mol

Synonyms:3-Morpholino-3-oxo-propionsaeure-aethylester;N-etossicarbonilacetilmorfolina;3-morpholino-3-oxo-propionic acid ethyl ester;3-p-tolyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester;3-(4-methoxyphenyl)-3-oxopropionic acid ethyl ester;3-morpholin-4-yl-3-oxo-propionic acid ethyl ester;ethyl 3-(4-morpholino)benzoate;ethyl(4-methoxybenzoyl)acetate;ethyl 3-(4-methoxyphenyl)-3-oxopropionate;Ethyl (p-methoxybenzoyl)acetate;3-oxo-3-(4-methoxyphenyl)propanoic acid ethyl ester;3-(4-Morpholinyl)-3-oxopropansaeure-ethylester;ethyl 3-morpholino-3-oxopropanoate;3-(p-Tolyl)-1,2,4-oxdiazol-5-carbonsaeure-aethylester;ethyl 3-(4-methylphenyl)-1,2,4-oxadiazol-5-carboxylate;ethyl 3-(4-morpholyl)-3-oxopropanoate;(4-Methoxybenzoyl)acetic acid,ethyl ester;ethyl 3-(morpholin-4-yl)benzoate;

Chemical Property of 3-Morpholin-4-yl-3-oxo-propionic acid ethyl ester

Chemical Property:

• Melting Point: 59.5 °C
• Boiling Point: 346.2±37.0 °C(Predicted)
• PKA: 14.81±0.20(Predicted)
• PSA: 55.84000
• Density: 1.164±0.06 g/cm3(Predicted)
• LogP: -0.26370
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 3-morpholin-4-yl-3-oxopropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Morpholin-4-yl-3-oxo-propionic acid ethyl ester

There total 10 articles about 3-Morpholin-4-yl-3-oxo-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

morpholine (110-91-8,99108-56-2) + ethyl potassium malonate (6148-64-7) → 3-(4-Morpholinyl)-3-oxopropansaeure-ethylester (37714-64-0)

Guidance literature:

With thionyl chloride; 1.) 2 h, reflux, 2.) 30 min, 20 degC;

Reference yield: 68.0%

morpholine (110-91-8,99108-56-2) + diethyl 2-nitro-3-oxopentanedioate (1010117-23-3) → nitroacetic acid ethyl ester (626-35-7) + 3-(4-Morpholinyl)-3-oxopropansaeure-ethylester (37714-64-0)

Guidance literature:

In chloroform; at 20 ℃; for 24h;

DOI:10.1246/bcsj.80.2413

Reference yield: 56.0%

3,3-Bis(morpholino)-2-propensaeure-ethylester (105545-73-1) → 3-(4-Morpholinyl)-3-oxopropansaeure-ethylester (37714-64-0)

Guidance literature:

With acetic acid; for 2h; Heating;

DOI:10.1055/s-1986-31711

upstream raw materials:

morpholine

diethyl malonate

ethyl potassium malonate

ethyl chlorocarbonylacetate

Downstream raw materials:

2-morfolino-4H-pirido<1,2-a>pirimidin-4-one

4-morfolino-2H-pirido<1,2-a>pirimidin-2-one

4-Chloro-2H-naphtho<1,2-b>pyran-2-one

2-(morpholin-4-yl)benzo[h]chromen-4-one

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AND USES THEREOF". Page/Page column 95. . Retrieved 2012/05/21.
• 2、 Zhang, Zhenhua,Liu, Yiyang,Ling, Lin,Li, Yuxue,Dong, Yian,Gong, Mingxing,Zhao, Xiaokun,Zhang, Yan,Wang, Jianbo. "Pd-catalyzed carbonylation of diazo compounds at atmospheric pressure: A catalytic approach to ketenes". supporting information; experimental part. p. 4330 - 4341. Retrieved 2011/06/21.