2-(Morpholin-4-yl)-benzo[h]chromen-4-one

Base Information

Chemical Name:2-(Morpholin-4-yl)-benzo[h]chromen-4-one
CAS No.:154447-35-5
Molecular Formula:C17H15NO3
Molecular Weight:281.30600
Hs Code.:
UNII:DJ7RQT66H6
DSSTox Substance ID:DTXSID10432010
Nikkaji Number:J2.014.476I
Wikidata:Q27088097
Pharos Ligand ID:CW49F76TH77T
ChEMBL ID:CHEMBL104468
Mol file:154447-35-5.mol

Synonyms:2-(morpholin-4-yl)benzo(h)chromen-4-one;NU 7026;NU-7026;NU7026

Suppliers and Price of 2-(Morpholin-4-yl)-benzo[h]chromen-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DNA-PK Inhibitor II
25mg
$ 275.00

Sigma-Aldrich
NU7026 ≥98% (HPLC), solid
5mg
$ 193.00

Sigma-Aldrich
DNA-PK Inhibitor II
5mg
$ 185.00

DC Chemicals
NU7026 >98%
1 g
$ 1500.00

Crysdot
NU7026 98+%
50mg
$ 363.00

ChemScene
NU7026 99.92%
50mg
$ 384.00

ChemScene
NU7026 99.92%
10mg
$ 96.00

ChemScene
NU7026 99.92%
5mg
$ 60.00

Cayman Chemical
NU 7026 ≥95%
10mg
$ 124.00

Cayman Chemical
NU 7026 ≥95%
5mg
$ 65.00

Total 26 raw suppliers

Chemical Property of 2-(Morpholin-4-yl)-benzo[h]chromen-4-one

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:267-269 °C(Solv: methanol (67-56-1); water (7732-18-5))
Boiling Point:459.879oC at 760 mmHg
PKA:0.49±0.20(Predicted)
Flash Point:231.927oC
PSA：42.68000
Density:1.331g/cm3
LogP:2.84780
Storage Temp.:2-8°C
Solubility.:DMSO: 3 mg/mL at 60 °C, soluble
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:281.10519334
Heavy Atom Count:21
Complexity:441

Purity/Quality:

99%, ^*data from raw suppliers

DNA-PK Inhibitor II ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
Uses DNA-PK Inhibitor II is an antiproliferative agent, and inhibitor of DNA-PK. NU7026 has been used:as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cellin kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Technology Process of 2-(Morpholin-4-yl)-benzo[h]chromen-4-one

There total 4 articles about 2-(Morpholin-4-yl)-benzo[h]chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 503469-16-7
1-(1-hydroxynaphth-2-yl)-3-(morpholin-4-yl)-propane-1,3-dione

: 154447-35-5
2-(morpholin-4-yl)benzo[h]chromen-4-one

Guidance literature:: With trifluoromethylsulfonic anhydride; In dichloromethane; at 0 ℃; for 20h;
DOI:10.1021/jm049526a

Reference yield:

: 1696-20-4
4-acetylmorpholine

: 154447-35-5
2-(morpholin-4-yl)benzo[h]chromen-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -10 °C

1.2: 78 percent / tetrahydrofuran; hexane / 16 h / 25 °C

2.1: 63 percent / triflic anhydride / CH₂Cl₂ / 20 h / 0 °C

With trifluoromethylsulfonic anhydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm049526a

Reference yield:

: 948-03-8
1-hydroxy-naphthalene-2-carboxylic acid methyl ester

: 154447-35-5
2-(morpholin-4-yl)benzo[h]chromen-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -10 °C

1.2: 78 percent / tetrahydrofuran; hexane / 16 h / 25 °C

2.1: 63 percent / triflic anhydride / CH₂Cl₂ / 20 h / 0 °C

With trifluoromethylsulfonic anhydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm049526a