amino(3-methoxyphenyl)acetonitrile

Base Information

• Chemical Name: amino(3-methoxyphenyl)acetonitrile
• CAS No.: 379232-33-4
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.191
• Mol file: 379232-33-4.mol

Synonyms:Amino-(3-methoxy-phenyl)-acetonitrile;DL-3-methoxyphenylglycine nitrile;

Chemical Property of amino(3-methoxyphenyl)acetonitrile

Chemical Property:

• PSA: 59.04000
• LogP: 1.91888

Purity/Quality:

2-Amino-2-(3-methoxyphenyl)acetonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of amino(3-methoxyphenyl)acetonitrile

There total 4 articles about amino(3-methoxyphenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-hydroxy-2-methylpropanenitrile (75-86-5) + 3-methoxy-benzaldehyde (591-31-1) → 2-amino-2-(3-methoxyphenyl)acetonitrile (379232-33-4)

Guidance literature:

3-methoxy-benzaldehyde; With lithium hexamethyldisilazane; In tetrahydrofuran; at 25 ℃; for 4h;

2-hydroxy-2-methylpropanenitrile; In tetrahydrofuran; at 25 ℃; for 12h;

DOI:10.1081/SCC-200043270

Reference yield: 82.0%

trimethylsilyl cyanide (7677-24-9) + 3-methoxy-benzaldehyde (591-31-1) → 2-amino-2-(3-methoxyphenyl)acetonitrile (379232-33-4)

Guidance literature:

With ammonia; In methanol; at 45 ℃; for 5h;

DOI:10.1021/ja0499389

Reference yield:

sodium cyanide (773837-37-9) + 3-methoxy-benzaldehyde (591-31-1) → 2-amino-2-(3-methoxyphenyl)acetonitrile (379232-33-4)

Guidance literature:

With ammonium hydroxide; ammonium acetate; In ethanol; water; at 25 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c6cc04308a DOI:10.1039/c7cc01304c

upstream raw materials:

potassium cyanide

3-methoxy-benzaldehyde

trimethylsilyl cyanide

2-hydroxy-2-methylpropanenitrile

Downstream raw materials:

(2S)-(+)-2-(3-Methoxyphenyl)glycin

DL-3-methoxyphenylglycine nitrile hydrochloride