5-Pyrimidinecarbonyl chloride, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo- (9CI)

Base Information

• Chemical Name: 5-Pyrimidinecarbonyl chloride, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo- (9CI)
• CAS No.: 38009-10-8
• Molecular Formula: C7H7ClN2O3
• Molecular Weight: 202.59500
• Hs Code.: 2933599090
• Mol file: 38009-10-8.mol

Synonyms:1,2,3,4-TETRAHYDRO-1,3-DIMETHYL-2,4-DIOXO-5-PYRIMIDINECARBONYL CHLORIDE;5-pyrimidinecarbonyl chloride,1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo;1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl chloride;1,3-Dimethyl-uracil-carbonsaeure-(5)-chlorid;

Chemical Property of 5-Pyrimidinecarbonyl chloride, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo- (9CI)

Chemical Property:

• PSA: 61.07000
• LogP: -0.53700

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinecarbonyl chloride, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo- (9CI)

There total 3 articles about 5-Pyrimidinecarbonyl chloride, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (4869-45-8) → 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride (38009-10-8)

Guidance literature:

With thionyl chloride; for 1.5h; Heating;

Reference yield:

2,4-dihydroxypyrimidine-5-carboxylic acid (23945-44-0,76821-79-9) → 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride (38009-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 12percent aq. KOH / 2.5 h / 20 °C

2: thionyl chloride / 1.5 h / Heating

With potassium hydroxide; thionyl chloride;

Reference yield:

→ 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride (38009-10-8)

Guidance literature:

6a, Thionylchlorid;

DOI:10.1002/cber.19721050635

upstream raw materials:

1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

2,4-dihydroxypyrimidine-5-carboxylic acid

Downstream raw materials:

methyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyridine-5-carboxylate