4,5,6,7-Tetrafluoro-2-methyl-2H-isoindole

Base Information

Chemical Name:4,5,6,7-Tetrafluoro-2-methyl-2H-isoindole
CAS No.:38053-09-7
Molecular Formula:C9H5F4N
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID50492512
Nikkaji Number:J2.276.582E
Wikidata:Q82338476

Synonyms:38053-09-7;4,5,6,7-Tetrafluoro-2-methyl-2H-isoindole;4,5,6,7-tetrafluoro-2-methylisoindole;DTXSID50492512;N-methyl-4,5,6,7-tetrafluoroisoindole;2-Methyl-4,5,6,7-tetrafluoroisoindole

Suppliers and Price of 4,5,6,7-Tetrafluoro-2-methyl-2H-isoindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,5,6,7-Tetrafluoro-2-methyl-2H-isoindole

Chemical Property:

Vapor Pressure:0.037mmHg at 25°C
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:203.03581181
Heavy Atom Count:14
Complexity:203

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=C2C(=C1)C(=C(C(=C2F)F)F)F

Technology Process of 4,5,6,7-Tetrafluoro-2-methyl-2H-isoindole

There total 5 articles about 4,5,6,7-Tetrafluoro-2-methyl-2H-isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 5875-75-2,145920-67-8
9-methyl-5,6,7,8-tetrafluoro-1,4-dihydronaphthalen-1,4-imine

: 38053-09-7
N-methyl-4,5,6,7-tetrafluoroisoindole

Guidance literature:: With 3,6-di(2'-pyridyl)-1,2,4,5-tetrazine; In chloroform; for 4h; Heating;
DOI:10.1021/jo00210a011

Reference yield: 58.2%

: 55164-85-7
4,5,6,7-tetrafluoro-2H-isoindole

: 74-88-4
methyl iodide

: 38053-09-7
N-methyl-4,5,6,7-tetrafluoroisoindole

Guidance literature:: 4,5,6,7-tetrafluoro-2H-isoindole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; for 14h; Inert atmosphere;

Reference yield:

: 344-07-0
1-chloro-2,3,4,5,6-pentafluorobenzene

: 38053-09-7
N-methyl-4,5,6,7-tetrafluoroisoindole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: 3,6-di(2'-pyridyl)-1,2,4,5-tetrazine / dichloromethane / 40 °C

With n-butyllithium; 3,6-di(2'-pyridyl)-1,2,4,5-tetrazine; In diethyl ether; hexane; dichloromethane; 1.1: |Diels-Alder Cycloaddition / 1.2: |Diels-Alder Cycloaddition;
DOI:10.1016/j.tetlet.2014.06.069