3-Quinolinecarbonitrile, 4-chloro-7-(4-chlorobutoxy)-6-methoxy-

Base Information

Chemical Name:3-Quinolinecarbonitrile, 4-chloro-7-(4-chlorobutoxy)-6-methoxy-
CAS No.:380844-38-2
Molecular Formula:C15H14Cl2N2O2
Molecular Weight:325.194
Hs Code.:
DSSTox Substance ID:DTXSID00471195
Wikidata:Q82299647
Mol file:380844-38-2.mol

Synonyms:380844-38-2;4-CHLORO-7-(4-CHLOROBUTOXY)-6-METHOXYQUINOLINE-3-CARBONITRILE;3-Quinolinecarbonitrile, 4-chloro-7-(4-chlorobutoxy)-6-methoxy-;SCHEMBL4487395;DTXSID00471195

Suppliers and Price of 3-Quinolinecarbonitrile, 4-chloro-7-(4-chlorobutoxy)-6-methoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 3-Quinolinecarbonitrile, 4-chloro-7-(4-chlorobutoxy)-6-methoxy-

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:324.0432331
Heavy Atom Count:21
Complexity:374

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C(=C(C=N2)C#N)Cl)OCCCCCl

Technology Process of 3-Quinolinecarbonitrile, 4-chloro-7-(4-chlorobutoxy)-6-methoxy-

There total 1 articles about 3-Quinolinecarbonitrile, 4-chloro-7-(4-chlorobutoxy)-6-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 928-51-8
4-Chloro-1-butanol

: 263149-10-6
4-chloro-7-hydroxy-6-methoxyquinolin-3-carbonitrile

: 380844-38-2
4-chloro-7-(4-chlorobutoxy)-6-methoxy-3-quinolinecarbonitrile

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 ℃; for 0.25h;
DOI:10.1021/jm0102250

Reference yield: 43.0%

: 98446-49-2
2,4-dichloro-5-methoxyaniline

: 380844-38-2
4-chloro-7-(4-chlorobutoxy)-6-methoxy-3-quinolinecarbonitrile

: 380844-44-0
7-(4-chlorobutoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile

Guidance literature:: With pyridine hydrochloride; In 2-ethoxy-ethanol; for 4h; Heating;
DOI:10.1021/jm0102250

Reference yield:

: 380844-38-2
4-chloro-7-(4-chlorobutoxy)-6-methoxy-3-quinolinecarbonitrile

: 4-(2,4-dichloro-5-methoxy-phenylamino)-6-methoxy-7-(4-morpholin-4-yl-butoxy)-quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / pyridine hydrochloride / 2-ethoxy-ethanol / 4 h / Heating

2: 47 percent / NaI / 1,2-dimethoxy-ethane / 90 °C

With pyridine hydrochloride; sodium iodide; In 2-ethoxy-ethanol; 1,2-dimethoxyethane;
DOI:10.1021/jm0102250