98446-49-2

Basic information

• Product Name: 2,4-Dichloro-5-methoxyaniline
• Synonyms: 2,4-DICHLORO-5-METHOXYANILINE;2,4-Dichloro-5-methoxybenzenamine;5-AMINO-4,6-DICHLOROANISOLE;BENZENAMINE,2,4-DICHLORO-5-METHOXY-;4,6-Dichloro-m-anisidine;2,4-dichloro-5-methoxyphenylamine;5-Amino-2,4-dichloroanisole, 4,5-Dichloro-m-anisidine;2,4-Dichloro-5-methoxyaniline 4,6-Dichloro-m-anisidine
• CAS NO: 98446-49-2
• Molecular Formula: C₇H₇Cl₂NO
• Molecular Weight: 192.04
• EINECS: 1312995-182-4
• Product Categories: Heterocyclic Compounds;Anilines, Amides & Amines;Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds
• Mol File: 98446-49-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 51 °C
• Boiling Point: 290.1 °C at 760 mmHg
• Flash Point: 129.3 °C
• Appearance: White or off-white powder
• Density: 1.375 g/cm³
• Vapor Pressure: 0.00211mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 1.59±0.10(Predicted)
• CAS DataBase Reference: 2,4-Dichloro-5-methoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-5-methoxyaniline(98446-49-2)
• EPA Substance Registry System: 2,4-Dichloro-5-methoxyaniline(98446-49-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: UN2810
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 98446-49-2(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-5-methoxyaniline is a chemical compound with the molecular formula C7H7Cl2NO. It is a derivative of aniline, which is used as a precursor for various pharmaceuticals and pesticides. 2,4-Dichloro-5-methoxyaniline is characterized by its two chlorine atoms and a methoxy group attached to the aniline ring. It is primarily used in the manufacture of dyes and pigments. Additionally, it has been studied for its potential as an intermediate in organic synthesis for the production of various pharmaceuticals. However, it is important to handle 2,4-Dichloro-5-methoxyaniline with caution, as it may have harmful effects on human health and the environment.

InChI:InChI=1/C7H7Cl2NO/c1-11-7-3-6(10)4(8)2-5(7)9/h2-3H,10H2,1H3

Upstream product

• 65182-98-1 N-(2,4-dichloro-5-methoxybenzene)acetamide 
• 24891-35-8 3-hydroxyformanilide 
• 591-27-5 m-Hydroxyaniline 
• 7206-70-4 4-amino-5-chloro-2-methoxybenzoic acid 
• 621-42-1 meta-hydroxyacetanilide 
• 67669-19-6 N-(2,4-dichloro-5-hydroxyphenyl)acetamide 

Downstream Products

• 364793-73-7 3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxyquinolin-7-yl trifluoromethanesulfonate 
• 622369-46-4 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 846023-24-3 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide 
• 700844-33-3 7-[(2, 4-dichloro-5-methoxyphenyl) amino]-2-phenylthieno [3,2-b] pyridine-6-carbonitrile 
• 1334396-29-0 C₂₀H₁₃Cl₂N₃O₂ 
• 1334309-74-8 C₂₇H₂₇Cl₂N₇O₂ 
• 1334310-77-8 C₂₈H₂₉Cl₂N₇O₂ 
• 1334312-08-1 C₂₈H₂₇Cl₂N₇O₂ 
• 1334310-22-3 C₂₉H₂₉Cl₂N₇O₂ 
• 1334310-95-0 C₂₆H₂₅Cl₂N₇O₂ 
• 1334309-46-4 C₂₇H₂₈Cl₂N₈O₂ 
• 1334396-27-8 C₂₈H₂₉Cl₂N₇O₂ 
• 1334310-23-4 C₂₉H₃₁Cl₂N₇O₂ 
• 1334311-68-0 C₂₈H₂₇Cl₂N₇O₂ 

Relevant articles and documents

Preparation method of mecitinib raw material (by machine translation)

The method comprises the following steps: preparing,methyl 3 -(-ethyl-)-amido phenol, dichloro - 5 5-methoxyaniline (by reaction with potassium chloride) sodium 2,4 - to generate (dichloro - 5 5-methan)-methaneth, 2,4 -amidobenzylether (in a chlorine substitution reaction). 2,4 - The method comprises the following steps: reacting m-methyl-methanethinonylphenol and hydrogen peroxide, to generate, dichloro - 5 5-methoxyaniline. The method comprises the following steps of reacting m-aminophenol as a raw material to synthesize methyl chloride 2,4 - potassium, and benzoyl (and reacting; with chloromethane in, a mixture) of, sodium, chloride and methyl chloride, and reacting with chloromethane in a reaction condition. (by machine translation)

A PROCESS FOR THE PREPARATION OF BOSUTINIB

The present invention provides an improved process for the preparation of bosutinib and its intermediate 2-cyano-N-(2, 4-dichloro-5-methoxyphenyl)acetamide.

Pd(II)-catalyzed bromo- and chlorodecarboxylation of electron-rich arenecarboxylic acids

A bromo- and chlorodecarboxylation of various aromatic carboxylic acids catalyzed by Pd(II) has been developed in this work. A series of electron-rich arenecarboxylic acids gave the corresponding decarboxylative monohalogenation products under the typical reaction conditions.