(E)-Ethyl 3-(4-(benzyloxy)-3-methoxyphenyl)acrylate

Base Information

• Chemical Name: (E)-Ethyl 3-(4-(benzyloxy)-3-methoxyphenyl)acrylate
• CAS No.: 38157-08-3
• Molecular Formula: C19H20O4
• Molecular Weight: 312.365
• European Community (EC) Number: 684-454-0
• Nikkaji Number: J2.402.540C
• Mol file: 38157-08-3.mol

Synonyms:(E)-Ethyl 3-(4-(benzyloxy)-3-methoxyphenyl)acrylate;38157-08-3;ethyl (E)-3-(3-methoxy-4-phenylmethoxyphenyl)prop-2-enoate;3-Methoxy-4-(benzyloxy)cinnamic acid ethyl ester;SCHEMBL5685435;MFCD00228704;AKOS025134660;DS-8816;CS-0061532;W17715;A873916;(E)-Ethyl3-(4-(benzyloxy)-3-methoxyphenyl)acrylate;ethyl 3-[4-(benzyloxy)-3-methoxyphenyl]prop-2-enoate;ETHYL (E)-3-(4-(BENZYLOXY)-3-METHOXYPHENYL)ACRYLATE

Chemical Property of (E)-Ethyl 3-(4-(benzyloxy)-3-methoxyphenyl)acrylate

Chemical Property:

• PSA: 44.76000
• LogP: 3.85050
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 312.13615911
• Heavy Atom Count: 23
• Complexity: 374

Purity/Quality:

97% ^*data from raw suppliers

(E)-Ethyl3-(4-(benzyloxy)-3-methoxyphenyl)acrylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C=CC1=CC(=C(C=C1)OCC2=CC=CC=C2)OC
• Isomeric SMILES: CCOC(=O)/C=C/C1=CC(=C(C=C1)OCC2=CC=CC=C2)OC

Technology Process of (E)-Ethyl 3-(4-(benzyloxy)-3-methoxyphenyl)acrylate

There total 10 articles about (E)-Ethyl 3-(4-(benzyloxy)-3-methoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → (E)-3-(4-benzyloxy-3-methoxyphenyl)acrylic acid ethyl ester (38157-08-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 6h;

DOI:10.1002/ejoc.201501009

Reference yield: 85.0%

(2S,3S)-3-Acetoxy-3-(4-benzyloxy-3-methoxy-phenyl)-2-bromo-propionic acid ethyl ester → (E)-3-(4-benzyloxy-3-methoxyphenyl)acrylic acid ethyl ester (38157-08-3)

Guidance literature:

With water; 1-methyl-3-pentyl-1H-imidazolium tetrafluoroborate; at 125 ℃; for 0.0583333h; under 2585.74 Torr; microwave irradiation;

DOI:10.1016/j.tet.2006.10.035

Reference yield: 76.0%

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) + ethyl bromoacetate (105-36-2) → (E)-3-(4-benzyloxy-3-methoxyphenyl)acrylic acid ethyl ester (38157-08-3)

Guidance literature:

With triphenylphosphine; nanocrystalline aerogel prepared MgO; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1002/adsc.200606001

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

3-methoxy-4-(phenylmethoxy)benzaldehyde

ethyl bromoacetate

ethyl (triphenylphosphoranylidene)acetate

Downstream raw materials:

3-(4-(benzyloxy)-3-methoxyphenyl)propiolic acid

ethyl 3-(3-ethoxy-4-hydroxyphenyl)propanoate

(1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol

(2S,3S)-3-(4-(benzyloxy)-3-methoxyphenyl)-2,3-dihydroxypropyl 4-methylbenzenesulfonate