3,7-Dioxa-1-azaspiro[5.5]undec-1-en-4-one, 2-phenyl-9,10,11-tris(phenylmethoxy)-8-[(phenylmethoxy)methyl]-, (6S,8R,9S,10S,11R)-

Base Information

Chemical Name:3,7-Dioxa-1-azaspiro[5.5]undec-1-en-4-one, 2-phenyl-9,10,11-tris(phenylmethoxy)-8-[(phenylmethoxy)methyl]-, (6S,8R,9S,10S,11R)-
CAS No.:381724-76-1
Molecular Formula:C43H41NO7
Molecular Weight:683.801
Hs Code.:
Mol file:381724-76-1.mol

Synonyms:

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Chemical Property of 3,7-Dioxa-1-azaspiro[5.5]undec-1-en-4-one, 2-phenyl-9,10,11-tris(phenylmethoxy)-8-[(phenylmethoxy)methyl]-, (6S,8R,9S,10S,11R)-

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MSDS Files:: SDS file from LookChem

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Technology Process of 3,7-Dioxa-1-azaspiro[5.5]undec-1-en-4-one, 2-phenyl-9,10,11-tris(phenylmethoxy)-8-[(phenylmethoxy)methyl]-, (6S,8R,9S,10S,11R)-

There total 3 articles about 3,7-Dioxa-1-azaspiro[5.5]undec-1-en-4-one, 2-phenyl-9,10,11-tris(phenylmethoxy)-8-[(phenylmethoxy)methyl]-, (6S,8R,9S,10S,11R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-47-0
benzonitrile

: 2-deoxy-α-D-galacto-oct-3-ulopyranosonic acid

: 381724-76-1
(6S,8R,9S,10S,11R)-9,10,11-Tris-benzyloxy-8-benzyloxymethyl-2-phenyl-3,7-dioxa-1-aza-spiro[5.5]undec-1-en-4-one

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/j.carres.2006.11.006

Reference yield:

: 82598-84-3
2,3,4,6-tetra-O-benzyl-D-galactonolactone

: 381724-76-1
(6S,8R,9S,10S,11R)-9,10,11-Tris-benzyloxy-8-benzyloxymethyl-2-phenyl-3,7-dioxa-1-aza-spiro[5.5]undec-1-en-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / tetrahydrofuran / 1 h / -78 - 20 °C

2: 100 percent / TFA / CH₂Cl₂ / 1.5 h / 0 °C

3: 92 percent / TMSOTf / CH₂Cl₂ / 0.17 h / 0 °C

With trimethylsilyl trifluoromethanesulfonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 3: Ritter reaction;
DOI:10.1055/s-2001-16797

Reference yield:

: 381724-74-9
((3R,4S,5S,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-2-hydroxy-tetrahydro-pyran-2-yl)-acetic acid tert-butyl ester

: 381724-76-1
(6S,8R,9S,10S,11R)-9,10,11-Tris-benzyloxy-8-benzyloxymethyl-2-phenyl-3,7-dioxa-1-aza-spiro[5.5]undec-1-en-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / TFA / CH₂Cl₂ / 1.5 h / 0 °C

2: 92 percent / TMSOTf / CH₂Cl₂ / 0.17 h / 0 °C

With trimethylsilyl trifluoromethanesulfonate; trifluoroacetic acid; In dichloromethane; 2: Ritter reaction;
DOI:10.1055/s-2001-16797